Olfr987 Activators
Olfr987, a member of the olfactory receptor (OR) family, is integral to the olfactory system, functioning as a detector for a variety of odorants. These receptors, including Olfr987, are categorized within the G-protein-coupled receptor (GPCR) superfamily, which plays a critical role in a wide range of physiological processes beyond olfaction. The activation of Olfr987, like other ORs, is contingent on the binding of specific odorant molecules, which triggers a cascade of intracellular signaling events leading to the transduction of these chemical signals into electrical signals in the olfactory neurons.
Upon binding of an odorant, Olfr987 undergoes a conformational change, which is a fundamental step in its activation process. This change facilitates the interaction of Olfr987 with G-proteins, leading to the activation of adenylate cyclase, an enzyme responsible for converting ATP to cyclic AMP (cAMP). The increase in cAMP levels is crucial, as it activates protein kinase A (PKA), which then phosphorylates various targets within the cell. This series of events ultimately results in the neuronal response that constitutes the perception of smell. The specificity of the interaction between odorant molecules and receptors like Olfr987 is key to the diversity and specificity of odor perception. Each receptor is tuned to detect particular molecular features, allowing the olfactory system to discriminate among a vast array of different odorants. The study of Olfr987 and its activators provides significant insights into the molecular mechanisms underlying olfaction. Understanding how specific chemicals activate this receptor can reveal much about the broader principles governing GPCR function, which is relevant not only in sensory perception but also in various other physiological contexts. Moreover, research in this area has implications for the development of novel therapies and interventions, as GPCRs are critical targets in pharmacology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Octen-3-ol | 3391-86-4 | sc-237604 | 25 g | $50.00 | ||
1-Octen-3-ol activates Olfr987 by binding to its orthosteric site, leading to a conformational change that facilitates G-protein coupling. This activation triggers adenylate cyclase, increasing cyclic AMP levels, and thereby activating PKA, resulting in the functional activation of Olfr987. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr987 through direct interaction with its ligand-binding domain. This interaction induces a conformational shift, enabling G-protein coupling and adenylate cyclase activation. The increase in cyclic AMP levels leads to PKA activation and functional activation of Olfr987. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr987 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels and activating PKA, thereby functionally activating Olfr987. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr987 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr987. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr987 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr987. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates Olfr987 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr987. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates Olfr987 by binding to the receptor's active site, causing a conformational shift. This shift facilitates G-protein coupling and activation, leading to adenylate cyclase stimulation, an increase in cyclic AMP, and activation of PKA, functionally activating Olfr987. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr987 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr987. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene activates Olfr987 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr987. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
(-)-trans-Caryophyllene activates Olfr987 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr987. | ||||||