Olfr983 Activators
Olfr983 is an olfactory receptor belonging to the G-protein-coupled receptor (GPCR) family, primarily expressed in the olfactory epithelium. It plays a crucial role in the detection of specific odorant molecules, translating chemical signals into neuronal responses. The activation of Olfr983 occurs through the binding of specific odorant molecules to its ligand-binding site, which induces conformational changes in the receptor. These changes allow Olfr983 to interact with G-proteins, leading to the activation of various intracellular signaling pathways. The most common pathway involves the stimulation of adenylate cyclase, which increases the intracellular concentration of cyclic AMP (cAMP). Elevated levels of cAMP activate protein kinase A (PKA), leading to phosphorylation of various cellular targets, ultimately translating into cellular responses such as neuronal firing or gene expression changes.
The mechanism of activation of Olfr983 is a quintessential example of GPCR signaling, showcasing the receptor's versatility in detecting a wide range of chemical stimuli and transducing these signals into cellular responses. The specificity of ligand binding to Olfr983 and the subsequent receptor activation are key to the distinct olfactory responses elicited by different odorants. The olfactory system, relying on receptors like Olfr983, exemplifies the intricacies of molecular recognition and signal transduction, demonstrating how specific chemical interactions at the receptor level can lead to varied and complex sensory experiences. This detailed understanding of receptor activation mechanisms provides insight into the broader principles of sensory perception and signal transduction in the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone activates Olfr983 by interacting with specific binding sites on the receptor. This interaction induces a structural alteration in Olfr983, initiating G-protein-coupled receptor signaling. The activated receptor stimulates adenylate cyclase, escalating cyclic AMP production and activating PKA, which then influences cellular responses. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr983 by binding to the receptor's ligand-binding domain. This binding event triggers G-protein coupling and activation, leading to the stimulation of adenylate cyclase, an increase in intracellular cyclic AMP, and the activation of PKA, which modulates various cellular functions. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin activates Olfr983 by binding directly to the receptor, inducing a conformational change. This activation stimulates G-protein signaling pathways, leading to the activation of adenylate cyclase, a rise in cyclic AMP levels, and the activation of PKA, influencing cellular responses. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene activates Olfr983 by interacting with its extracellular domain, leading to a structural rearrangement. This rearrangement facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP production, and activating PKA, which affects various cellular activities. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole activates Olfr983 through its direct binding to the receptor, causing a conformational change. This activation stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, an increase in cyclic AMP levels, and subsequent activation of PKA, affecting cellular functions. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
Anethole activates Olfr983 by binding to the receptor's active site, causing a conformational shift. This shift facilitates the coupling of the receptor with G-proteins, leading to the stimulation of adenylate cyclase, increased cyclic AMP levels, and the activation of PKA, influencing cellular responses. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde activates Olfr983 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and subsequently activating PKA, affecting various cellular processes. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr983 by binding to its orthosteric site, inducing a conformational change in the receptor. This change facilitates G-protein coupling and activation, leading to adenylate cyclase stimulation, increased cyclic AMP production, and the activation of PKA, influencing cellular responses. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr983 by binding to the receptor's ligand-binding domain. This binding triggers G-protein coupling and activation, leading to the stimulation of adenylate cyclase, an increase in cyclic AMP, and the activation of PKA, modulating various cellular functions. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr983 by interacting with specific binding sites on the receptor, inducing a structural alteration. This alteration facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, influencing cellular activities. | ||||||