Olfr919 Activators
Olfr919 is an integral part of the olfactory receptor protein family, playing a crucial role in the olfactory system's ability to detect and differentiate a wide range of odorant molecules. As a G-protein coupled receptor (GPCR), Olfr919 is essential in the mechanism of converting chemical stimuli from the environment into neural signals, fundamental to the perception of scents. The functional activation of Olfr919, similar to other olfactory receptors, begins with the binding of specific odorant molecules to the receptor. This binding results in a conformational change in the protein, which is the key to initiating the signal transduction pathway.
The specificity of the interaction between Olfr919 and odorant molecules is vital for the selective detection of odors. Each olfactory receptor, including Olfr919, has unique binding sites that are structurally compatible with certain odorant molecules. Compounds such as phenyl ethyl alcohol, linalool, and citronellol, when bound to Olfr919, induce structural changes that trigger the activation of the receptor's associated G-proteins. This activation leads to a series of intracellular signaling events, including the generation of secondary messengers like cyclic AMP and an increase in intracellular calcium levels. These messengers amplify the olfactory signal, resulting in a neural response. This mechanism of activation allows for the accurate perception of a wide range of odors, underlining the sophistication and efficiency of the olfactory system. Furthermore, the ability of Olfr919 to be activated by various chemicals with distinct structural characteristics highlights the broad specificity of olfactory receptors. This broad specificity enables the olfactory system to discern a diverse array of odorant molecules, each providing a unique sensory experience. The precise interaction of these chemicals with Olfr919 is essential for the accurate functioning of the olfactory system, facilitating the detection and perception of odors. This interaction is fundamental to our sense of smell, significantly influencing our daily experiences and interactions with the environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol activates Olfr919 by binding to its olfactory receptor sites, inducing a conformational change in the protein. This interaction triggers the activation of G-protein coupled signaling pathways, leading to increased intracellular calcium levels and cyclic AMP, crucial for the functional activation and signal transduction of Olfr919, enhancing the perception of its floral and rose-like odor. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool, with its floral and lavender-like aroma, activates Olfr919 through binding to its specific olfactory receptor sites. This binding induces a structural alteration in Olfr919, initiating the activation of G-protein coupled intracellular signaling pathways. These pathways, particularly those involving the elevation of cyclic AMP, are essential for the functional activation of Olfr919, facilitating olfactory signal transmission. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol activates Olfr919 by interacting with its olfactory binding sites. This interaction results in a conformational change in Olfr919, leading to the activation of downstream G-protein coupled pathways. The activation of these pathways, especially those that increase cyclic AMP levels, is crucial for the functional activation and signal transduction of the olfactory receptor Olfr919. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, known for its sweet and floral scent, activates Olfr919 by binding to its olfactory receptor sites. This binding triggers a change in the receptor's conformation, activating associated G-protein coupled signaling pathways. These pathways, including the rise in intracellular calcium and cyclic AMP levels, are crucial for the functional activation and proper signal transduction of Olfr919. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol activates Olfr919 by binding to its olfactory receptor sites, causing a conformational change in the receptor. This change facilitates the activation of G-protein coupled pathways, resulting in intracellular signaling events. The increase in cyclic AMP, particularly, is essential for the functional activation of Olfr919, playing a key role in the perception of nerol's fresh floral odor. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a compound with a lemony and citrusy odor, activates Olfr919 by interacting with its specific olfactory receptor binding sites. This interaction causes a change in the receptor's structure, triggering the activation of G-protein coupled signal transduction pathways. The activation of these pathways, especially those involving cAMP, is vital for the functional activation of Olfr919, enhancing the perception of its scent. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $31.00 $102.00 $408.00 | ||
Benzyl alcohol activates Olfr919 through molecular binding at its specific olfactory receptor sites. This binding induces a conformational change in Olfr919, leading to the activation of downstream G-protein coupled pathways. These pathways are essential for the transduction of olfactory signals mediated by Olfr919, particularly the increase in cyclic AMP levels. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol, known for its clove-like aroma, activates Olfr919 by binding to its olfactory receptor sites. This interaction induces a structural alteration in Olfr919, leading to the activation of G-protein coupled intracellular signaling pathways. The activation of these pathways, especially those resulting in the increase of intracellular calcium levels, is crucial for the functional activation of Olfr919. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol activates Olfr919 by binding to its olfactory receptor sites, causing a conformational change. This interaction facilitates the activation of G-protein coupled pathways, leading to a series of intracellular signaling events. These events, particularly the increase in cyclic AMP, are essential for the functional activation of Olfr919, contributing to the perception of its spicy and woody odor. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin, with its sweet and creamy aroma, activates Olfr919 by interacting with its specific olfactory receptor sites. This binding induces a structural change in Olfr919, triggering the activation of G-protein coupled signaling pathways. The activation of these pathways, including increased intracellular calcium levels, is vital for the functional activation of the olfactory receptor Olfr919. | ||||||