Olfr899 Activators
Olfr899 is an olfactory receptor protein responsible for detecting specific odorants and initiating the olfactory signal transduction pathway. Its activation is crucial for our ability to perceive and distinguish various scents in our environment. The primary function of Olfr899 is to recognize and respond to specific odorant molecules. This recognition occurs when odorant molecules, such as Ethyl Cinnamate or Octanal, bind directly to Olfr899's receptor site, triggering a conformational change that activates the receptor. This activation leads to the initiation of intracellular signaling cascades through G-proteins, ultimately resulting in the functional activation of Olfr899 in olfactory signal transduction.
Indirect activators, like 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) or Forskolin, enhance Olfr899's sensitivity to odorants by modulating the cAMP-PKA pathway. These chemicals increase the phosphorylation of olfactory receptors, including Olfr899, amplifying their responsiveness to odorants and facilitating their functional activation in odor detection. In summary, Olfr899 plays a crucial role in our sense of smell, and its activation is orchestrated by a diverse range of chemicals that either directly bind to the receptor or indirectly modulate intracellular pathways, enhancing its sensitivity to odorants and enabling us to perceive and differentiate various scents in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal directly activates Olfr899 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr899 in olfactory signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol directly activates Olfr899 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This results in the functional activation of Olfr899 in olfactory signal transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde directly activates Olfr899 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr899 in olfactory signal transduction. | ||||||
Isobutyl phenylacetate | 102-13-6 | sc-269265 | 25 g | $69.00 | ||
Isobutyl Phenylacetate directly activates Olfr899 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr899 in olfactory signal transduction. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) indirectly activates Olfr899 by enhancing cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors. This amplifies the receptor's sensitivity to odorants and promotes the functional activation of Olfr899 in odor detection. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol indirectly activates Olfr899 by up-regulating its expression through specific signaling pathways. This enhances the synthesis of Olfr899 protein, resulting in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal indirectly activates Olfr899 by modulating the olfactory signaling pathway, leading to increased cAMP levels. This, in turn, enhances the activity of olfactory receptors like Olfr899 and facilitates their functional activation in odor detection. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol indirectly activates Olfr899 by binding to beta-adrenergic receptors on olfactory neurons. This activation triggers the cAMP-PKA pathway, enhancing the sensitivity of olfactory receptors, including Olfr899, to odorants and promoting their functional activation in odor detection. | ||||||
3-Methyl-2-oxovaleric Acid | 1460-34-0 | sc-484817 | 1 g | $326.00 | ||
3-Methyl-2-oxovaleric acid indirectly activates Olfr899 by influencing the olfactory signal transduction pathway. It enhances the production of cAMP, leading to increased PKA activity, which promotes the functional activation of Olfr899 by amplifying the receptor's response to odorant molecules. | ||||||