Olfr837 Activators
Olfr837, a member of the olfactory receptor gene family, plays a critical role in our sense of smell. This specific receptor is responsible for detecting and discriminating various odorant molecules in the environment. When odorants bind to Olfr837, a series of molecular events are initiated, ultimately leading to the activation of olfactory sensory neurons and the perception of associated scents.
The activation of Olfr837 primarily occurs through direct binding of odorant molecules to its receptor site, inducing a conformational change in the protein. This change triggers signal transduction pathways, such as the modulation of cyclic nucleotide-gated (CNG) channels, the influence on intracellular calcium signaling, and the stimulation of the cAMP-PKA pathway. Additionally, some chemicals act as allosteric modulators, enhancing the receptor's sensitivity to odorants. These diverse mechanisms result in the functional activation of Olfr837, allowing it to fulfill its role in olfactory signal transduction and our ability to perceive and differentiate various scents. Understanding the specific activation mechanisms of Olfr837 is crucial in unraveling the complex processes of olfaction and contributes to our comprehension of how we perceive and distinguish different odors in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Menthol activates Olfr837 by directly binding to the receptor and inducing a conformational change. This binding triggers the receptor's downstream signaling pathways, leading to functional activation of Olfr837 and subsequent olfactory signal transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde activates Olfr837 by modulating the cyclic nucleotide-gated (CNG) channels in olfactory sensory neurons. It enhances channel opening, allowing an influx of cations and subsequent receptor activation, resulting in the functional activation of Olfr837 and the perception of specific scents. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr837 by influencing intracellular calcium signaling in olfactory sensory neurons. It promotes calcium influx, which triggers the activation of Olfr837 and the transmission of olfactory signals, ultimately leading to the functional activation of the receptor. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene activates Olfr837 through the modulation of olfactory ciliary ion channels. It enhances channel activity, resulting in increased membrane depolarization and receptor activation. This activation leads to the functional activation of Olfr837 and the perception of specific odors associated with α-Pinene. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
Ethyl Vanillin activates Olfr837 by acting as an allosteric modulator of the receptor, enhancing its sensitivity to certain odorant molecules. This modulation amplifies receptor activation and downstream signaling, ultimately leading to the functional activation of Olfr837 and the perception of specific scents. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr837 by directly binding to the receptor and stabilizing its active conformation. This interaction prolongs receptor activation and subsequent signaling, leading to the functional activation of Olfr837 and the perception of scents associated with Geraniol. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $29.00 | ||
Isovaleric Acid activates Olfr837 by influencing the cAMP-PKA pathway. It stimulates adenylyl cyclase, increasing cAMP levels, which activate protein kinase A (PKA). PKA then leads to the functional activation of Olfr837, contributing to olfactory signal transduction and odor perception. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Allyl Isothiocyanate activates Olfr837 by promoting the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG) through the phospholipase C (PLC) pathway. This activation pathway leads to receptor activation and functional activation of Olfr837, allowing the perception of specific odors associated with Allyl Isothiocyanate. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal activates Olfr837 by increasing the release of neurotransmitters, such as glutamate, at the synapses of olfactory sensory neurons. This enhanced neurotransmitter release triggers receptor activation and the functional activation of Olfr837, contributing to olfactory signal transmission and scent perception. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole activates Olfr837 by enhancing olfactory ciliary ion channels' activity. This modulation leads to increased membrane depolarization and receptor activation, ultimately resulting in the functional activation of Olfr837 and the perception of specific odors associated with Anethole. | ||||||