Olfr770 Activators
Olfr770, a member of the olfactory receptor gene family, serves as a vital component in the intricate process of olfaction. This gene encodes a G-protein coupled receptor (GPCR) located within the sensory neurons of the olfactory epithelium. Its primary function lies in the detection and discrimination of specific odorant molecules present in the surrounding environment. These odorants exhibit a diverse range of chemical structures, yet Olfr770 exhibits a remarkable specialization in recognizing and transducing their presence into neuronal signals. Activation of Olfr770 initiates a highly orchestrated cascade of intracellular events, ultimately leading to the generation of electrical signals. These signals trigger neural responses that we perceive as our sense of smell.
The activation of Olfr770 represents a finely-tuned and specific process. It commences with the binding of odorant molecules to specific sites on the receptor's surface, where the unique chemical structure of each odorant fits precisely into the receptor's binding pocket, akin to a lock and key mechanism. This binding event induces a crucial conformational change in the receptor, serving as the molecular switch for activation. This conformational alteration, in turn, stimulates associated G-proteins, particularly Gαolf. The activated Gαolf protein initiates a downstream signaling cascade by enhancing the activity of adenylate cyclase, leading to the conversion of ATP to cyclic AMP (cAMP). Elevated cAMP levels result in the opening of ion channels, permitting the influx of calcium and sodium ions into the sensory neuron. This influx generates neuronal depolarization, subsequently initiating action potentials that are transmitted to the olfactory bulb in the brain, where odor information is further processed and interpreted. In conclusion, Olfr770's crucial role in olfaction highlights the complexity and specificity of the biochemical and cellular mechanisms underlying our sense of smell. Its activation is triggered by specific odorant molecules, each acting as a key to unlock the receptor's signaling potential. The biochemical processes involved in Olfr770's activation showcase the intricate nature of our sensory perception systems and provide a foundation for understanding sensory biology and related technological advancements.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate directly activates Olfr770 by binding to the receptor's active site, triggering a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $42.00 $106.00 | 3 | |
Diallyl sulfide acts as a direct activator of Olfr770 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction leads to an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene serves as a direct activator of Olfr770 by binding to the receptor's active site, promoting a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate directly activates Olfr770 by binding to the receptor's active site, triggering a conformational change that enhances its functional activity. This interaction leads to an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate is a direct activator of Olfr770, binding to a specific site on the receptor and promoting its functional activation. This interaction results in an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool directly activates Olfr770 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction leads to an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate activates Olfr770 by influencing the downstream G-protein coupled signaling pathway associated with the gene. It enhances the coupling efficiency between the receptor and intracellular effectors, amplifying signal transduction and gene activation in response to odorant binding. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $46.00 | ||
1-Octanol is a direct activator of Olfr770, binding to a specific site on the receptor and promoting its functional activation. This interaction results in an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-pinene serves as a direct activator of Olfr770 by binding to the receptor's active site, promoting a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol directly activates Olfr770 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction leads to an intensified response to odorant molecules, improving gene expression and olfactory perception. | ||||||