Olfr749 Inhibitors
Olfr749, an olfactory receptor gene found in Mus musculus (house mouse), plays a pivotal role in initiating the neuronal response responsible for the perception of smells. As a member of the G-protein-coupled receptor (GPCR) family, Olfr749 shares a 7-transmembrane domain structure with neurotransmitter and hormone receptors. Its function involves recognizing odorant molecules and mediating the transduction of odorant signals through G protein-mediated pathways. This gene belongs to the extensive olfactory receptor gene family, known for its unique nomenclature within the mouse genome.
Inhibition of Olfr749 can be achieved through various mechanisms, including the targeting of signaling pathways critical to its function. These inhibitors impact the ATP-gated P2X3 receptor, cAMP signaling pathway, GRK2-mediated receptor desensitization, MAPK pathway, and intracellular calcium signaling. Additionally, some inhibitors act as antagonists at metabotropic glutamate receptors and modulate calcium signaling, affecting olfactory signal amplification. By disrupting these pathways or processes, Olfr749's function is compromised, leading to reduced sensitivity to odorant molecules and ultimately inhibiting its role in smell perception. Understanding the inhibition of Olfr749 provides valuable insights into the complex mechanisms governing olfaction in mice. These inhibitors shed light on potential avenues for research in unraveling the intricate processes underlying odorant signal transduction. Further studies in this area can enhance our comprehension of olfactory receptor function and its regulation, contributing to a deeper understanding of sensory perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol indirectly inhibits Olfr749 by acting on the cAMP signaling pathway. It inhibits phosphodiesterase III (PDE3), leading to increased cAMP levels, disrupting the downstream activation of Olfr749, ultimately inhibiting the gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits Olfr749 by targeting the MAPK pathway, a downstream signaling pathway. It specifically inhibits MEK1, disrupting the activation of transcription factors necessary for Olfr749 expression, indirectly inhibiting the gene. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM inhibits Olfr749 by blocking intracellular calcium signaling. It is a cell-permeable calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr749 to odorant molecules and inhibiting its function. | ||||||
LY 341495 | 201943-63-7 | sc-361244 sc-361244A | 1 mg 10 mg | $87.00 $219.00 | 1 | |
LY341495 acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. It leads to reduced activation of Olfr749 and inhibition of its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 interferes with the MAPK pathway downstream of Olfr749. This disruption hinders the activation of transcription factors necessary for Olfr749 expression, indirectly inhibiting the gene. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine inhibits Olfr749 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr749 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB202190 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr749. This disruption hinders the activation of transcription factors essential for Olfr749 expression, indirectly inhibiting the gene. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits Olfr749 by disrupting intracellular calcium signaling. It specifically targets the endoplasmic reticulum calcium ATPase (SERCA), leading to decreased sensitivity of Olfr749 to odorant molecules and inhibiting its function. | ||||||
MPEP hydrochloride | 96206-92-7 | sc-279454A sc-279454 | 10 mg 50 mg | $133.00 $510.00 | ||
MPEP acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. It leads to reduced activation of Olfr749 and inhibition of its function. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine inhibits Olfr749 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr749 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||