Olfr749 Activators
Olfr749, as a member of the olfactory receptor (OR) family, is a specialized G-protein coupled receptor (GPCR) crucial for the sense of smell. These receptors are tasked with detecting and responding to a myriad of odorant molecules, allowing for the discrimination of a wide array of scents. Olfr749 is distinct in its structural configuration, enabling it to selectively bind specific volatile compounds. This specificity is key to the olfactory system's capability to identify and differentiate various odors. The ability of Olfr749 to respond to certain odorants underscores its role in the intricate tapestry of olfactory perception. The activation mechanism of Olfr749 is initiated upon the binding of an odorant molecule. This interaction is highly selective and triggers a cascade of biochemical events within the receptor. When an appropriate ligand, such as the chemicals listed in the table, binds to Olfr749, it undergoes a conformational change. This structural alteration is pivotal in activating the receptor. The subsequent activation of the associated G-protein marks the beginning of the signal transduction process. The G-protein then stimulates a series of intracellular events, often involving the generation of second messengers like cyclic AMP (cAMP). These messengers play a crucial role in amplifying the initial olfactory signal, resulting in a cellular response that culminates in the transmission of a nerve impulse to the brain, where it is interpreted as a distinct odor.
The array of chemicals identified as activators of Olfr749, including ethyl acetate, cinnamyl alcohol, and linalool, showcases the receptor's ability to respond to various odorants. This highlights the intricate nature of the olfactory system, where minor variations in molecular structure can lead to the activation of different receptors, contributing to the nuanced perception of smells. The functioning of Olfr749 in detecting these odorant molecules emphasizes the complexity and sophistication of the olfactory system, underscoring the significance of GPCRs in sensory perception. This process is vital not only for environmental perception but also plays a significant role in behaviors, memories, and emotions associated with different scents.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate, a compound with a sweet and fruity aroma, can activate Olfr749 by directly binding to it. This ester induces a conformational change in the receptor, activating the associated G-protein, leading to signaling pathways responsible for the perception of fruity scents. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $32.00 $104.00 $416.00 | ||
Benzyl alcohol, with its mild, floral aroma, can activate Olfr749. It interacts with the receptor, triggering a conformational change and activating downstream G-protein mediated signaling pathways, essential in olfactory perception processes. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $71.00 $95.00 | ||
3-Methyl-1-butanol, with a banana-like odor, can activate Olfr749 through direct binding. As an alcohol, it interacts with olfactory receptors by binding to them, leading to the activation of the G-protein coupled receptor pathway, a key mechanism in the detection of banana-like odors. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, known for its wintergreen odor, can activate Olfr749 by direct interaction. Upon binding, it triggers a conformational change in the receptor, leading to G-protein mediated signaling pathways for the perception of minty scents. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, present in lavender and other aromatic plants, can activate Olfr749 by binding to the receptor. This interaction induces a conformational change, leading to G-protein activation and signaling pathways crucial for the detection of floral and spicy odors. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol, a constituent of rose and geranium oils, can activate Olfr749 through direct binding. Its interaction with the receptor activates the G-protein, initiating signaling pathways necessary for the perception of floral scents. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate, known for its floral and fruity aroma, can activate Olfr749 by binding to the receptor. This interaction induces a conformational change, leading to the activation of G-protein signaling pathways crucial for the detection of floral and fruity odors. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, with a sweet rose-like aroma, can activate Olfr749 by directly interacting with the receptor. This binding induces a conformational change, leading to G-protein activation and signaling pathways important for the perception of rose-like odors. | ||||||