Olfr699 Inhibitors
Olfr699, also known as Olfactory Receptor Family 2 Subfamily AG Member 17, is a critical component of the olfactory system in Mus musculus (house mouse). Its primary function is to interact with odorant molecules present in the nasal passages, initiating a neuronal response that ultimately leads to the perception of various smells. Like other olfactory receptors, Olfr699 belongs to the extensive family of G-protein-coupled receptors (GPCRs), characterized by their unique 7-transmembrane domain structure, which is also shared with numerous neurotransmitter and hormone receptors. This structure allows Olfr699 to play a central role in recognizing and transducing odorant signals, enabling the sense of smell. It is noteworthy that the nomenclature assigned to olfactory receptor genes and proteins in this organism is distinct from that of other organisms, emphasizing their unique characteristics. Inhibiting Olfr699 poses a unique challenge due to its involvement in signal transduction rather than traditional enzymatic or structural functions. Therefore, the chemical inhibition of Olfr699 typically relies on indirect mechanisms that target the intricate intracellular signaling pathways associated with olfaction. Several chemicals, including those modulating cAMP, MEK/ERK, JNK, JAK kinases, AKT, Wnt, NF-κB, p38 MAPK, PI3-kinase, PLC-IP3, and GPCR desensitization pathways, have been identified as potential indirect inhibitors of Olfr699. These chemicals exert their inhibitory effects by disrupting downstream events necessary for proper olfactory receptor gene expression and function.
In conclusion, Olfr699 plays a pivotal role in the house mouse's ability to detect and distinguish odors, contributing significantly to their sensory perception. Inhibiting Olfr699 requires a nuanced approach that involves the modulation of complex signaling pathways associated with olfaction. While direct chemical inhibitors may be elusive, understanding the potential indirect inhibitors and their impact on olfactory pathways enhances our comprehension of sensory biology. Further research and experimental validation are essential to elucidate the precise mechanisms of Olfr699 inhibition and their implications in the field of olfaction.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor, indirectly impacting Olfr699 by elevating intracellular cAMP levels in olfactory neurons. Increased cAMP enhances olfactory signal transduction, thereby influencing Olfr699 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK/ERK pathway inhibitor, indirectly affecting Olfr699. By blocking this pathway, it disrupts the downstream signaling events that regulate olfactory receptor gene expression, leading to inhibition of Olfr699. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a specific JNK inhibitor, indirectly affecting Olfr699 by interfering with the JNK signaling pathway involved in olfactory signal transduction. Inhibition of JNK disrupts the downstream events crucial for olfactory receptor function. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib inhibits JAK kinases, indirectly influencing Olfr699 expression by disrupting downstream events essential for proper olfactory receptor function. JAK kinases are involved in olfactory receptor signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3-kinase inhibitor that impacts the AKT pathway in olfactory neurons. By inhibiting this pathway, it indirectly affects Olfr699 expression, as the AKT pathway regulates downstream events related to olfactory receptor gene expression. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is a tankyrase inhibitor that modulates the Wnt pathway, indirectly affecting Olfr699. By disrupting the Wnt pathway, it interferes with cellular processes necessary for proper olfactory receptor function and gene expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor, indirectly suppressing Olfr699. NF-κB is involved in regulating olfactory receptor function and gene expression, and its inhibition disrupts these processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels in olfactory neurons. This elevation in cAMP indirectly upregulates Olfr699 expression by enhancing odorant signal transduction through the cAMP pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that impacts the PLC-IP3 pathway in olfactory neurons. By inhibiting this pathway, it indirectly influences Olfr699 by disrupting the intracellular signaling processes required for proper olfactory receptor function. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a JAK2 inhibitor, indirectly influencing Olfr699 expression by disrupting downstream events essential for proper olfactory receptor function. JAK2 kinases are involved in olfactory receptor signaling pathways. | ||||||