Olfr695 Inhibitors
Olfr695, also known as Olfactory Receptor Family 2 Subfamily AG Member 13, is a crucial component of the olfactory system in Mus musculus (house mouse). It belongs to the family of olfactory receptors, which play a pivotal role in the detection and initial processing of odorant molecules in the nasal passages. These olfactory receptors are a part of the G-protein-coupled receptor (GPCR) superfamily, characterized by a 7-transmembrane domain structure, shared with other neurotransmitter and hormone receptors. Olfr695, like its counterparts, is responsible for recognizing odorants and initiating signaling cascades mediated by G proteins, ultimately leading to the perception of smell. The olfactory receptor gene family is the most extensive in the genome, and the nomenclature assigned to these genes and proteins in Mus musculus is unique to this organism.
Inhibition of Olfr695 presents challenges, primarily due to its role in signal transduction rather than conventional enzymatic or structural functions. As a result, the chemical inhibition of Olfr695 typically involves indirect mechanisms that target the intricate intracellular signaling pathways associated with olfaction. A variety of chemicals, including those modulating cAMP, cGMP, MEK/ERK, JNK, JAK kinases, AKT, Wnt, NF-κB, and GPCR desensitization pathways, can indirectly influence Olfr695. These chemicals exert their effects by disrupting downstream events required for proper olfactory receptor gene expression and function. In conclusion, Olfr695 plays a vital role in the house mouse's ability to detect and discriminate odors, contributing to their sensory perception. Inhibiting Olfr695 involves the modulation of complex signaling pathways related to olfaction. While direct chemical inhibitors may be elusive, understanding the potential indirect inhibitors and their effects on olfactory pathways enhances our understanding of sensory biology. Further research and experimental validation are necessary to elucidate the precise mechanisms of Olfr695 inhibition and their implications in the field of olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib inhibits PARP enzymes, indirectly affecting Olfr695 expression by modulating the DNA repair pathways in olfactory neurons. Disruption of DNA repair processes can lead to changes in olfactory receptor gene expression and function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK/ERK pathway inhibitor, indirectly influencing Olfr695. By blocking this pathway, it disrupts the downstream signaling events that regulate olfactory receptor gene expression, leading to inhibition of Olfr695. | ||||||
SB 239063 | 193551-21-2 | sc-220094B sc-220094 sc-220094A | 500 µg 5 mg 25 mg | $119.00 $162.00 $645.00 | 7 | |
SB-239063 is a specific JNK inhibitor, which indirectly affects Olfr695 by interfering with the JNK signaling pathway involved in olfactory signal transduction. Inhibition of JNK disrupts the downstream events crucial for olfactory receptor function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that impacts the AKT pathway in olfactory neurons. By inhibiting this pathway, it indirectly affects Olfr695 expression, as the AKT pathway regulates downstream events related to olfactory receptor gene expression. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $110.00 $337.00 | 8 | |
Wedelolactone inhibits NF-κB signaling in olfactory neurons, indirectly suppressing Olfr695. NF-κB is involved in regulating olfactory receptor function and gene expression, and its inhibition disrupts these processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP increases cAMP levels, affecting the cAMP-PKA pathway in olfactory neurons. By modulating this pathway, it indirectly inhibits Olfr695, disrupting the downstream events necessary for olfactory receptor activation and signal transduction. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $67.00 $278.00 | 3 | |
LY303511 is a PI3-kinase inhibitor that impacts the PLC-IP3 pathway in olfactory neurons. By inhibiting this pathway, it indirectly influences Olfr695 by disrupting the intracellular signaling processes required for proper olfactory receptor function. | ||||||
Compound 101 | 161125-36-6 | sc-507528 | 5 mg | $108.00 | ||
This chemical acts as a G protein-coupled receptor kinase 3 (GRK3) inhibitor, promoting GPCR desensitization in olfactory neurons. By enhancing GPCR desensitization, it indirectly inhibits Olfr695 and reduces the responsiveness of olfactory receptors, including Olfr695. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is known to interfere with cAMP levels and PKA activity in olfactory neurons. By modulating these aspects, it indirectly affects Olfr695 expression, disrupting the downstream signaling events necessary for proper olfactory receptor function. | ||||||