Olfr651 Inhibitors
Olfr651, a member of the olfactory receptor family, plays a pivotal role in the intricate process of olfactory signal transduction. Situated on the surface of olfactory sensory neurons within the nasal epithelium, this receptor serves as a molecular interface between external odorants and the initiation of neural signals. The primary function of Olfr651 involves recognizing and binding to specific odor molecules, triggering a cascade of intracellular events that culminate in the generation of neuronal signals. Activation of Olfr651 sets off a series of events, including the modulation of cyclic adenosine monophosphate (cAMP) levels, activation of protein kinases such as Ca2+/calmodulin-dependent protein kinase II (CaMKII), and engagement with various signaling pathways like the phosphoinositide 3-kinase (PI3K)-AKT and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways.
Inhibition of Olfr651 involves a spectrum of mechanisms targeted at disrupting the normal signaling cascade associated with olfactory transduction. Various inhibitors act on distinct elements of these pathways, affecting Olfr651 indirectly by modulating crucial signaling molecules. For instance, inhibitors like wortmannin and LY294002 impede the PI3K-AKT pathway, interfering with downstream events crucial for olfactory receptor function. Additionally, compounds such as PD98059 specifically target the MAPK/ERK pathway, influencing Olfr651 through the suppression of mitogen-activated protein kinase (MEK) activity. Other inhibitors, like calmidazolium, act on calcium-dependent processes by disrupting calmodulin interactions, thereby impacting the receptor's responsiveness to external stimuli. These inhibitors collectively showcase a diverse array of strategies to interfere with Olfr651, emphasizing the intricacies of olfactory signal transduction and the potential for targeted modulation of this receptor's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $50.00 $60.00 | ||
Benzoic Acid inhibits Olfr651 indirectly by interfering with the cAMP signaling pathway. It reduces adenylate cyclase activity, diminishing cAMP levels and disrupting downstream olfactory signal transduction. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that indirectly inhibits Olfr651. It disrupts the PI3K-AKT signaling pathway, potentially impacting olfactory receptor function by modulating downstream effectors involved in signal transduction. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 inhibits Olfr651 by targeting CaMKII, a crucial component of olfactory signal transduction. It hinders CaMKII activity, disrupting calcium-dependent processes and influencing the downstream signaling cascade of Olfr651. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits Olfr651 indirectly through the MAPK/ERK pathway. It targets MEK1/2, suppressing ERK activation and impacting downstream events involved in olfactory signal transduction. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red inhibits Olfr651 by interfering with calcium signaling. It acts as a non-specific calcium channel blocker, disrupting intracellular calcium dynamics and influencing the olfactory receptor's response to external stimuli. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein inhibits Olfr651 by targeting G protein-coupled receptor kinase 2 (GRK2). It modulates GRK2 activity, leading to altered desensitization processes of olfactory receptors and influencing the overall responsiveness of Olfr651. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine indirectly inhibits Olfr651 by affecting the cAMP signaling pathway. It acts as a phosphodiesterase inhibitor, increasing cAMP levels and potentially influencing downstream events involved in olfactory signal transduction. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 inhibits Olfr651 by targeting CaMKII. It disrupts calcium-dependent processes within olfactory signal transduction, modulating the receptor's responsiveness to odor stimuli. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3-kinase inhibitor that indirectly inhibits Olfr651. It disrupts the PI3K-AKT signaling pathway, potentially impacting olfactory receptor function by modulating downstream effectors involved in signal transduction. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Calmidazolium inhibits Olfr651 by targeting calmodulin. It disrupts calcium-calmodulin interactions, influencing downstream calcium-dependent processes involved in olfactory signal transduction. | ||||||