Olfr60 Activators
Olfr60, a member of the olfactory receptor family, is crucial in the detection and discrimination of odorous compounds. These receptors, classified under the G-protein-coupled receptor (GPCR) superfamily, are key in the olfactory process, allowing organisms to perceive and interpret a wide array of scents. The functional activation of Olfr60 is essential in this sensory process, enabling the recognition and differentiation of different odors. The activation mechanism of Olfr60 involves the direct binding of specific chemical ligands to the receptor. This interaction is highly selective, ensuring that Olfr60 is activated by distinct odorant molecules. Upon ligand binding, Olfr60 undergoes a significant conformational change, marking the initiation of its activation. This structural change is pivotal for the activation of the associated G-protein, typically G_olf in olfactory neurons. The activation process includes the exchange of GDP for GTP on the G_α subunit of the G-protein, followed by its dissociation from the G_βγ dimer. This dissociation leads to the activation of adenylate cyclase III, catalyzing the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels results in the opening of cyclic nucleotide-gated ion channels, facilitating the influx of calcium and sodium ions. This ion movement generates an electrical signal that is conveyed to the brain, resulting in the perception of a specific odor.
The direct activation of Olfr60 by various chemical ligands underscores the precision and complexity of the olfactory system. This specificity in ligand-receptor interaction is essential for accurate odor detection and differentiation, highlighting the intricate relationship between chemical compounds and biological receptors. The process of olfactory perception, as demonstrated by the activation of Olfr60, showcases the sophisticated biological mechanisms underlying sensory systems. The functional activation of Olfr60 by these odorant molecules not only emphasizes its role in olfactory perception but also provides insights into the broader principles of receptor-ligand interactions within biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr60 by directly binding to its specific odorant-binding site, inducing a conformational change essential for receptor activation. This interaction triggers G-protein signaling pathways, crucial for olfactory signal transduction. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate engages Olfr60 by interacting with its ligand-binding domain, causing a structural change in the receptor and activating it. This leads to the initiation of G-protein coupled signaling pathways essential for olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool activates Olfr60 through direct binding to its odorant receptor site, causing a conformational alteration and subsequent activation of the receptor. This initiates G-protein signaling cascades vital for olfactory perception. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol binds to Olfr60, inducing a structural change that activates the receptor. This activation facilitates the propagation of signal transduction pathways linked to olfactory receptor activation. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $29.00 | 1 | |
Benzyl acetate directly binds to Olfr60, resulting in receptor activation. This interaction triggers a series of G-protein mediated signaling events, fundamental to the function of olfactory receptors in scent detection. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $40.00 | ||
Geranyl acetate interacts with Olfr60 at its odorant-binding site, activating the receptor. This activation triggers G-protein mediated signaling pathways, essential for the transduction of olfactory signals. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr60 by binding to its ligand-specific site, causing a conformational change and initiating the activation of G-protein signaling mechanisms important for olfactory processing. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, by binding to Olfr60, activates the receptor and initiates a series of G-protein mediated signaling events, crucial for olfactory signal detection and interpretation. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates Olfr60 through direct ligand-receptor interaction, inducing a structural alteration essential for receptor activation and triggering G-protein signaling pathways involved in olfactory signal processing. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamic Aldehyde binds to Olfr60, causing receptor activation through a structural change. This activation leads to the initiation of G-protein mediated signaling pathways, essential for the perception of specific odors. | ||||||