Olfr598 Inhibitors
Olfr598, an olfactory receptor, stands at the intersection of intricate cellular signaling pathways, orchestrating vital processes within the cell. Functioning as a sensory receptor, Olfr598 is primarily involved in detecting and transducing signals from olfactory stimuli, playing a pivotal role in the perception of odors. Beyond its olfactory function, emerging evidence suggests that Olfr598 is intricately linked to various cellular processes, influencing gene expression and cellular responses. Its activation is closely tied to signaling cascades, notably the MAPK, PI3K/Akt, and JNK pathways, which are integral to the regulation of cellular survival, proliferation, and stress response.
Inhibition of Olfr598 involves a strategic interplay of chemical inhibitors targeting key components of these signaling pathways. Direct inhibitors disrupt specific activation events crucial for Olfr598 function, impeding the receptor's ability to transduce signals and modulate downstream gene expression. These inhibitors act on tyrosine residues, kinases, and other essential elements within the MAPK, PI3K/Akt, and JNK pathways, intricately controlling Olfr598's involvement in cellular processes. Additionally, indirect inhibitors influence related pathways, such as TGF-β and FGFR signaling, thereby modulating Olfr598 function by altering cellular responses linked to differentiation, migration, and gene expression regulation. The diversity of these inhibitors provides a nuanced approach to selectively perturb Olfr598, unraveling its intricate role in cellular processes beyond its canonical olfactory function. Understanding the mechanisms of Olfr598 inhibition not only contributes to unraveling the complexities of olfactory perception but also sheds light on its broader cellular impact, opening avenues for further exploration in cellular and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Lapatinib, a dual kinase inhibitor, directly inhibits Olfr598 by targeting specific tyrosine residues crucial for its activation. This leads to disruption of downstream signaling cascades, notably inhibiting the MAPK and PI3K pathways, vital for Olfr598 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a potent inhibitor by binding irreversibly to PI3K, a key player in Olfr598 signaling. By obstructing PI3K activity, Wortmannin disrupts the downstream Akt pathway, thereby indirectly inhibiting Olfr598 and impairing its functional role in cellular processes. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2, a selective Src kinase inhibitor, directly targets Olfr598 by impeding Src-mediated phosphorylation events crucial for its activation. This inhibition disrupts downstream signaling pathways, including the JAK-STAT pathway, essential for Olfr598 functionality. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly influences Olfr598 by blocking p38 MAPK activation. This interruption hampers Olfr598-associated signal transduction pathways, including the JNK pathway, thereby leading to the inhibition of Olfr598 function at the cellular level. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK1 and MEK2 inhibitor, directly targets Olfr598 by disrupting the MAPK/ERK pathway. This interference inhibits Olfr598 activation and impedes downstream transcriptional events, specifically hindering its role in modulating gene expression related to cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, an inhibitor of PI3K, directly hinders Olfr598 by interfering with the PI3K/Akt pathway. This disruption negatively impacts Olfr598 function by impeding downstream signaling, particularly influencing the regulation of cellular survival and proliferation processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, directly inhibits Olfr598 by targeting the JNK signaling pathway. This interference disrupts key events in Olfr598 activation, affecting downstream processes involved in cellular response to stress and influencing Olfr598's regulatory role in these pathways. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib, an EGFR kinase inhibitor, directly targets Olfr598 by inhibiting EGFR-mediated phosphorylation events essential for its activation. This inhibition disrupts downstream signaling cascades, including the Ras/Raf/MEK/ERK pathway, crucial for Olfr598 functionality. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a selective MEK inhibitor, directly inhibits Olfr598 by disrupting the MAPK/ERK pathway. This interference impedes Olfr598 activation and downstream transcriptional events, affecting its role in regulating gene expression linked to cellular processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, directly hinders Olfr598 by suppressing mTOR-mediated signaling. This suppression disrupts downstream pathways involved in protein synthesis and cellular growth, impacting Olfr598's functional role in regulating these fundamental cellular processes. | ||||||