Olfr593 Activators
Olfr593 is an olfactory receptor that plays a vital role in the detection and discrimination of odorous compounds. As a member of the G-protein-coupled receptor (GPCR) family, Olfr593 is involved in the intricate process of olfaction, which is fundamental to the perception of the olfactory environment. The functional activation of Olfr593 is a critical step in the olfactory signal transduction pathway, enabling organisms to interpret a wide range of scents. The activation mechanism of Olfr593 involves the direct binding of specific chemical ligands to the receptor. This binding is highly selective, ensuring that Olfr593 is activated by distinct odorant molecules, each contributing to the unique sensory experience of smell. Upon ligand binding, Olfr593 undergoes a significant conformational change, marking the initial phase of its activation. This change in structure is crucial for activating the associated G-protein, typically G_olf in olfactory neurons. The activation process includes the exchange of GDP for GTP on the G_α subunit of the G-protein, followed by its dissociation from the G_βγ dimer. This event leads to the activation of adenylate cyclase III, catalyzing the conversion of ATP to cyclic AMP (cAMP). The rise in cAMP levels causes the opening of cyclic nucleotide-gated ion channels, leading to the influx of calcium and sodium ions. This ion movement generates an electrical signal that is conveyed to the brain, where it is perceived as a distinct odor.
The activation of Olfr593 by specific chemical activators illustrates the precision and complexity of the olfactory system. This specificity is essential for the accurate detection and differentiation of odors, highlighting the intricate relationship between chemical compounds and biological receptors in sensory perception. The process of olfactory perception, as demonstrated by the activation of Olfr593, underscores the sophisticated mechanisms underlying sensory systems. The direct activation of Olfr593 by various odorant molecules not only emphasizes the receptor's role in the sense of smell but also reflects the broader principles of receptor-ligand interactions in biological systems. This understanding of Olfr593 and its activation contributes to the broader knowledge of GPCRs and their role in sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr593 by directly binding to its specific odorant-binding site, initiating a conformational change essential for receptor activation. This leads to the activation of G-protein signaling pathways, crucial for olfactory signal transduction. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate engages with Olfr593 by interacting with its ligand-binding domain. This binding causes a structural change in the receptor, triggering the activation of intracellular signal transduction mechanisms associated with olfactory G-protein coupled receptors. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr593 through direct binding to its odorant receptor site, inducing a conformational alteration and subsequent activation of the receptor. This activation initiates G-protein signaling cascades vital for olfactory perception. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
(±)-β-Citronellol binds to Olfr593, inducing a structural change that activates the receptor. This activation facilitates the propagation of signal transduction pathways linked to olfactory receptor activation, contributing to sensory perception. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate directly binds to Olfr593, resulting in receptor activation. This interaction triggers a series of G-protein mediated signaling events, fundamental to the function of olfactory receptors in scent detection. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate interacts with Olfr593 at its odorant-binding site, activating the receptor. This activation triggers G-protein mediated signaling pathways, which are essential for the transduction of olfactory signals. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr593 by binding to its ligand-specific site, causing a conformational change and initiating the activation of G-protein signaling mechanisms important for olfactory processing. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, by binding to Olfr593, activates the receptor and initiates a series of G-protein mediated signaling events, crucial for olfactory signal detection and interpretation. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates Olfr593 through direct ligand-receptor interaction, inducing a structural alteration essential for receptor activation and triggering G-protein signaling pathways involved in olfactory signal processing. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde binds to Olfr593, causing receptor activation through a structural change. This activation leads to the initiation of G-protein mediated signaling pathways, essential for the perception of specific odors. | ||||||