Olfr59 Activators
Olfr59, an olfactory receptor, is a member of the G-protein-coupled receptor (GPCR) superfamily, specifically involved in the detection of odorant molecules. These receptors are essential for the sense of smell, allowing organisms to perceive and differentiate a wide range of volatile compounds. Olfr59, like its counterparts, operates through the binding of specific odorant molecules, which triggers a series of intracellular events leading to the perception of smell.
The mechanism of Olfr59 activation is rooted in the direct binding of odorant molecules to the receptor. This interaction is highly specific, with Olfr59 responding to distinct chemical compounds. Upon ligand binding, Olfr59 undergoes a conformational change that is critical for its activation. This structural change in the receptor is the primary event in the signal transduction pathway. Following this, the receptor activates its associated G-protein, G_olf in olfactory neurons. The activation involves the exchange of GDP for GTP on the G_α subunit, followed by its dissociation from the G_βγ dimer. The G_α subunit then interacts with adenylate cyclase III, catalyzing the conversion of ATP to cyclic AMP (cAMP), a secondary messenger. This increase in cAMP levels leads to the opening of cyclic nucleotide-gated ion channels, resulting in the influx of calcium and sodium ions into the cell, which generates an electrical signal. This signal is then transmitted to the brain, where it is interpreted as a distinct smell. The direct activation of Olfr59 by specific chemical ligands is a finely tuned process, ensuring precise detection and discrimination of odors. This specificity is essential for the diverse range of olfactory experiences. The activation of Olfr59 and its subsequent signal transduction pathway highlights the intricate nature of olfactory perception, demonstrating the complex interplay between chemical ligands and biological receptors in sensory systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr59 by directly binding to its ligand-binding domain, triggering a conformational change essential for receptor activation. This binding induces a series of intracellular responses through G-protein signaling pathways, specifically tailored to olfactory receptor activation. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate engages Olfr59 by directly interacting with its odorant binding site. This interaction initiates a structural change in the receptor, leading to the activation of downstream G-protein coupled pathways integral to olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr59 through direct binding to its specific receptor site, causing a conformational alteration and activating the receptor. This activation initiates G-protein signaling cascades crucial for olfactory signal perception and processing. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral binds and activates Olfr59 by interacting with its odorant-binding site. This interaction induces receptor conformational change, which in turn activates G-protein mediated pathways, essential for transmitting olfactory signals. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate directly binds to Olfr59, causing receptor activation. This interaction results in the initiation of G-protein mediated signal transduction pathways, which play a critical role in olfactory sensory responses. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates Olfr59 by direct binding to its odorant receptor site, triggering a change in receptor conformation and activating G-protein coupled signaling mechanisms involved in olfactory perception. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene binds specifically to Olfr59, leading to its activation. This binding triggers a cascade of G-protein mediated signaling events, vital for the function of olfactory receptors in scent detection. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, by directly interacting with Olfr59, activates the receptor. This activation is key to initiating intracellular signaling cascades mediated by G-proteins, integral to the olfactory response mechanism. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol activates Olfr59 through direct ligand-receptor interaction, inducing a structural change essential for receptor activation. This interaction triggers G-protein signaling pathways, crucial for the olfactory signal processing. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol binds and activates Olfr59 by inducing a conformational alteration in the receptor, leading to the activation of G-protein coupled pathways essential for olfactory signal transmission. | ||||||