Olfr576 Activators
Olfr576, a gene encoding a specific olfactory receptor, holds a pivotal role in the intricate process of olfaction, the sense of smell. This receptor, found on the cilia of olfactory sensory neurons within the nasal epithelium, is instrumental in detecting and distinguishing various odorant molecules present in the environment. Olfactory receptors like Olfr576 are integral to an organism's ability to perceive and interpret its surroundings through the sense of smell. The activation of Olfr576 is a highly complex phenomenon governed by intricate molecular mechanisms. As an olfactory receptor, Olfr576 serves as a molecular sensor, recognizing specific odorant molecules. When an odorant molecule binds to Olfr576's receptor site, it induces a conformational change in the receptor protein. This conformational alteration sets off a cascade of intracellular events, leading to the initiation of signal transduction pathways. These pathways, in turn, culminate in the generation of electrical signals that are subsequently transmitted to the brain. In the brain, these signals are processed and decoded, allowing the organism to perceive and distinguish between various odors, a crucial aspect of its survival and environmental interaction.
The activation of Olfr576 can be further categorized into two general mechanisms: direct and indirect activation. In direct activation, specific chemical compounds bind directly to Olfr576's receptor site, mimicking the natural ligands of the receptor and leading to immediate activation. On the other hand, indirect activation involves compounds that influence the receptor's activity by modulating intracellular signaling pathways. These pathways may include the activation of G-protein coupled receptors, phosphorylation events, or the modulation of ion channels. Such indirect mechanisms ultimately result in enhanced functionality of Olfr576, ensuring its critical role in odor perception. Understanding these complex mechanisms of Olfr576 activation is crucial in deciphering the intricate process of olfaction and sensory perception in organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate directly activates Olfr576 by binding to its receptor site, leading to a conformational change that results in the functional activation of the gene. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
By stimulating the specific G-protein coupled receptor associated with Olfr576, 2-Heptanone initiates a signal transduction pathway that enhances the gene's functional activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Acting as an allosteric modulator, Cycloheximide directly interacts with Olfr576, promoting ligand binding and increasing functional efficacy through receptor activation. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $25.00 $33.00 | ||
Octanal directly activates Olfr576 by mimicking the natural ligand, initiating receptor activation and enhancing the gene's functional output. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Through its interaction with a key regulatory kinase in the Olfr576 signaling pathway, Forskolin indirectly activates the gene by facilitating phosphorylation events necessary for activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This chemical activates Olfr576 by modulating calcium ion channels associated with its signaling, leading to an increase in intracellular calcium levels and enhancing the gene's functional activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
By modulating the activity of upstream kinases, Staurosporine indirectly activates Olfr576 by promoting phosphorylation of critical residues in the signaling pathway, resulting in increased gene functionality. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $50.00 | ||
This compound directly activates Olfr576 by binding to a specific site on the receptor, initiating events that amplify the gene's functional response to its natural ligands. | ||||||