Olfr541 Inhibitors
Olfr541, a member of the olfactory receptor family, stands as a key participant in olfactory signal transduction, playing a crucial role in the detection and discrimination of specific odorants. Functionally, Olfr541 is integral to the intricate process of olfactory perception, acting as a molecular sensor that initiates cascades of events upon binding to its cognate ligands. This receptor enables organisms to interpret and respond to a diverse array of olfactory stimuli, contributing to their ability to navigate and interact with their environment based on distinct smells.
The inhibition of Olfr541 involves a sophisticated interplay with various signaling pathways, particularly those associated with epidermal growth factor receptors (EGFR), vascular endothelial growth factor receptors (VEGFR), and fibroblast growth factor receptors (FGFR). Inhibitors such as Gefitinib, Lapatinib, and Erlotinib directly target the EGFR pathway, disrupting Olfr541 activation by inhibiting kinase activities and hindering downstream cascades crucial for Olfr541 function. Additionally, compounds like Nintedanib and AZD4547 modulate the VEGFR and FGFR pathways, respectively, altering phosphorylation events crucial for Olfr541 function and downstream signaling. The diverse mechanisms employed by these inhibitors underscore the intricacies of Olfr541 inhibition, providing valuable insights into potential strategies for controlling olfactory signal transduction at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
EGFR inhibitor disrupting the EGFR pathway linked to Olfr541 activation. Modulates intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
Afatinib | 439081-18-2 | sc-364398 sc-364398A | 5 mg 10 mg | $112.00 $194.00 | 13 | |
Irreversible EGFR/HER2 inhibitor affecting the EGFR pathway linked to Olfr541. Alters intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
AZD8931 | 848942-61-0 | sc-364426 sc-364426A | 5 mg 10 mg | $260.00 $490.00 | ||
Dual EGFR/HER2/HER3 inhibitor modulating the EGFR pathway associated with Olfr541 activation. Impedes kinase activities, disrupting phosphorylation events crucial for Olfr541 function and downstream signaling. | ||||||
Canertinib | 267243-28-7 | sc-207397 | 10 mg | $260.00 | 3 | |
Irreversible EGFR/HER2 inhibitor affecting the EGFR pathway linked to Olfr541. Alters intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
Vandetanib | 443913-73-3 | sc-220364 sc-220364A | 5 mg 50 mg | $167.00 $1353.00 | ||
Multikinase inhibitor targeting VEGFR, EGFR, and RET pathways associated with Olfr541. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr541 function. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Dual EGFR/HER2 inhibitor disrupting the EGFR pathway linked to Olfr541. Alters intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
EGFR inhibitor modulating the EGFR pathway associated with Olfr541 activation. Modulates intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
AEE 788 | 497839-62-0 | sc-480425 | 10 mg | $4665.00 | ||
Dual EGFR/VEGFR inhibitor affecting the EGFR pathway linked to Olfr541. Modulates intracellular signaling by inhibiting EGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||
BIBF1120 | 656247-17-5 | sc-364433 sc-364433A | 5 mg 10 mg | $180.00 $315.00 | 2 | |
Triple angiokinase inhibitor targeting VEGFR, PDGFR, and FGFR pathways associated with Olfr541. Impedes kinase activities, disrupting phosphorylation events crucial for Olfr541 function and downstream signaling. | ||||||
AZD4547 | 1035270-39-3 | sc-364421 sc-364421A | 5 mg 10 mg | $198.00 $309.00 | 6 | |
FGFR inhibitor modulating the FGFR pathway linked to Olfr541. Alters intracellular signaling by inhibiting FGFR kinase activity, hindering downstream cascades crucial for Olfr541 function. | ||||||