Olfr5 Inhibitors
Olfr5, a crucial member of the olfactory receptor protein family, serves as a molecular gateway to the intricate process of olfactory perception. Positioned within the nasal environment, Olfr5 operates as a G-protein-coupled receptor (GPCR), tasked with the detection and transduction of signals emanating from odorant molecules. Structurally characterized by a 7-transmembrane domain shared with neurotransmitter and hormone receptors, Olfr5 is an integral component of the vast gene family responsible for recognizing and transmitting olfactory signals. The coding-exon genes that give rise to olfactory receptors contribute to the unparalleled diversity within this family, making it the largest in the genome. Notably, the nomenclature assigned to olfactory receptor genes and proteins for this organism is independent of other organisms, highlighting the uniqueness of olfactory signaling in each species.
The inhibition of Olfr5 involves a sophisticated interplay of chemical agents that can act either directly or indirectly to modulate its function. Direct inhibitors exert their impact by specifically targeting components of signaling pathways associated with Olfr5. For instance, inhibitors such as MEK inhibitors or p38 MAPK inhibitors directly interfere with the MAPK pathway, disrupting downstream elements crucial for olfactory signal transduction. On the other hand, indirect inhibitors operate by influencing cellular processes related to Olfr5 function. Calcium channel blockers or PI3K inhibitors may impact Olfr5 by modulating intracellular calcium levels or disrupting the PI3K-Akt pathway, respectively. These alterations in cellular processes ultimately impact G-protein-mediated transduction, thereby influencing the neuronal response to odorant signals and potentially altering the perception of odors in the olfactory system. The complexity of these inhibitory mechanisms underscores the intricate web of signaling pathways involved in olfactory signal transduction and provides valuable insights into the regulatory networks governing Olfr5 within the molecular landscape of smell perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein, a Gβγ inhibitor, directly inhibits Olfr5 by disrupting G-protein signaling. Its interference with G-protein-mediated transduction could impact the neuronal response involved in olfactory signal transduction, affecting the perception of smell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, directly inhibits the MAPK pathway. By disrupting this pathway, it may influence downstream elements affecting Olfr5, potentially altering G-protein-coupled receptor signaling and impacting olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
PTX (Pertussis toxin) inhibits G-protein signaling. Olfr5, being a GPCR, may be indirectly affected, as pertussis toxin disrupts G-protein-mediated transduction. This interference could alter the neuronal response to odorant signals in the olfactory system. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly influence Olfr5 by inhibiting the PI3K-Akt pathway. Modulating this pathway could impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, could indirectly impact Olfr5 by modulating intracellular calcium levels. Changes in calcium signaling may affect G-protein-mediated transduction and alter the neuronal response to odorant molecules, impacting olfactory perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly targets the MAPK pathway. Inhibition of this pathway may affect downstream elements involved in olfactory signal transduction, potentially influencing Olfr5 and altering the perception of odors in the olfactory system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, could indirectly influence Olfr5 by disrupting the PI3K-Akt pathway. Modulating this pathway may impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA inhibitor, may indirectly inhibit Olfr5 by disrupting calcium homeostasis. Changes in intracellular calcium levels could influence G-protein-mediated transduction, altering the neuronal response to odorant signals and impacting olfactory perception. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93, a CaMKII inhibitor, may indirectly affect Olfr5 by modulating calcium/calmodulin-dependent signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X, a PKC inhibitor, may indirectly influence Olfr5 by modulating PKC-mediated signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||