Olfr491 Inhibitors
Olfr491, belonging to the olfactory receptor protein family, is a critical player in the olfactory system, orchestrating the complex process of odorant perception. As a member of the G-protein-coupled receptor (GPCR) family, Olfr491 is a molecular sensor that interacts with odorant molecules, initiating a neuronal response that culminates in the perception of smell. The structural framework of Olfr491, characterized by a 7-transmembrane domain, aligns it with numerous neurotransmitter and hormone receptors. This shared structure highlights its role in the recognition and G protein-mediated transduction of odorant signals, contributing to the intricate machinery of olfactory transduction.
The inhibition of Olfr491 involves a diverse array of mechanisms, each impacting different facets of the receptor's function. Various inhibitors target key components within intracellular signaling pathways associated with olfactory transduction. For instance, some inhibitors interfere with calcium release or chelate intracellular calcium, disrupting downstream events essential for proper olfactory transduction. Others suppress kinases within the MAPK pathway, indirectly inhibiting Olfr491 by altering downstream signaling, leading to diminished activation of the receptor and subsequent reduction in the perception of odorant stimuli. Blockade of adenylate cyclase or purinergic receptors also hinders olfactory signal transduction, contributing to the inhibition of Olfr491. Overall, the inhibition of Olfr491 showcases the complexity of modulating its activity, requiring a nuanced understanding of the intricate signaling networks involved in olfactory perception. These diverse mechanisms provide valuable insights into potential strategies for influencing olfactory function and offer a foundation for further exploration of olfactory receptor modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Inhibits Olfr491 by blocking IP3 receptor-mediated calcium release, disrupting downstream signaling essential for proper olfactory transduction and diminishing the perception of smell. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Targets purinergic receptors, indirectly inhibiting Olfr491 by interfering with extracellular signaling events that modulate olfactory receptor activity, resulting in reduced odor perception. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Suppresses MEK in the MAPK pathway, indirectly inhibiting Olfr491 by disrupting downstream signaling, leading to altered neuronal responses and reduced perception of odorant stimuli. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Blocks Src family kinases, interfering with intracellular signaling cascades involved in olfactory transduction, and subsequently inhibiting Olfr491, leading to reduced perception of smell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3-kinase, affecting intracellular signaling pathways associated with olfactory transduction. By indirectly suppressing Olfr491, it alters neuronal responses and reduces odor perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Targets p38 MAPK, impacting the MAPK pathway and indirectly inhibiting Olfr491. This disruption alters downstream signaling, leading to reduced activation of the receptor and diminished smell perception. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Chelates intracellular calcium, disrupting downstream events in olfactory transduction. By indirectly inhibiting Olfr491, it alters neuronal responses, diminishing the perception of odorant stimuli. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK in the MAPK pathway, indirectly suppressing Olfr491 by disrupting downstream signaling events crucial for proper olfactory transduction and diminishing the perception of smell. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
Inhibits adenylate cyclase, disrupting cAMP signaling and GPCR-mediated transduction of olfactory signals. This impedes Olfr491 activation, diminishing the neuronal response and smell perception. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Targets PKC, a component of the cAMP signaling pathway, indirectly inhibiting Olfr491 by disrupting GPCR-mediated transduction of olfactory signals, resulting in reduced activation of the receptor. | ||||||