Olfr461 Inhibitors
Olfr461, a crucial member of the olfactory receptor family, plays a fundamental role in initiating neuronal responses to odorant molecules, culminating in the perception of smell. As a G-protein-coupled receptor (GPCR), Olfr461 shares structural characteristics with neurotransmitter and hormone receptors, serving as a pivotal mediator in the complex process of odorant signal transduction. The olfactory receptor gene family, epitomized by Olfr461, stands as the largest in the genome, underscoring its significance in olfactory perception.
The inhibition of Olfr461 involves a diverse array of chemical interventions targeting various GPCR-associated pathways. Rapamycin, an mTOR inhibitor, suppresses mTOR-dependent events, impacting downstream GPCR signaling pathways and indirectly inhibiting Olfr461. Wortmannin disrupts PI3-kinase-dependent processes involved in GPCR-mediated signal transduction. Thapsigargin influences calcium signaling by inhibiting the SERCA pump, potentially impacting Olfr461 through calcium-dependent processes. Furthermore, NF-κB inhibitor modulates NF-κB signaling, affecting GPCR-related pathways, while BAPTA-AM, a calcium chelator, alters calcium-dependent processes. SB203580, a p38 MAP kinase inhibitor, impacts MAPK signaling, and LY294002 inhibits PI3-kinase, both potentially influencing Olfr461 function through their respective pathways. These inhibitors provide valuable insights into potential interventions for Olfr461, elucidating the intricate mechanisms involved in olfactory signal transduction at the molecular level.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting cellular processes associated with olfactory signal transduction. Indirectly inhibits Olfr461 by suppressing mTOR-dependent events, impacting downstream GPCR signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor altering intracellular signaling pathways. Indirectly influences olfactory receptor function by disrupting PI3-kinase-dependent processes involved in GPCR-mediated signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor influencing calcium signaling. Disrupts GPCR-related pathways by modulating intracellular calcium levels, potentially impacting Olfr461 function through calcium-dependent processes in olfactory signal transduction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor disrupting MAPK pathway. Influences GPCR-mediated signal transduction, potentially inhibiting Olfr461 function through the downstream modulation of MAPK signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Modulator of NF-κB signaling impacting GPCR-related pathways. Alters intracellular processes, potentially inhibiting Olfr461 function through the disruption of NF-κB-mediated cascades involved in olfactory signal transduction. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Intracellular calcium chelator affecting GPCR-mediated signal transduction. Alters calcium-dependent processes, indirectly influencing Olfr461 function by modulating downstream signaling cascades. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor impacting MAPK signaling pathways. Modulates cellular responses downstream of GPCR activation, potentially inhibiting Olfr461 function through the MAPK cascade. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3-kinase inhibitor impacting GPCR-related signaling pathways. Modulates intracellular processes, indirectly influencing Olfr461 function through the disruption of PI3-kinase-dependent cascades. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
PKC inhibitor targeting downstream GPCR signaling. Modifies intracellular pathways involved in olfactory signal transduction, potentially inhibiting Olfr461 function through PKC-mediated processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor affecting the MAPK pathway. Alters GPCR-related signal transduction, potentially inhibiting Olfr461 function through downstream modulation of the MAPK cascade. | ||||||