Olfr458 Activators
Chemical activators of Olfr458, such as Heptanal, α-Ionone, and β-Ionone, function by directly interacting with the ligand-binding domain of the protein. These chemicals induce conformational changes in Olfr458, crucial for activating the G-protein coupled receptor (GPCR) pathway. Upon binding of these activators, there is a stimulation of adenylate cyclase, subsequently elevating intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA) and other downstream signaling molecules, leading to various cellular responses.
Chemicals including Camphor, Citronellal, and Eucalyptol share a similar mechanism in activating Olfr458. They bind to specific sites on the protein, initiating a cascade of intracellular events. This binding not only alters the protein conformation but also effectively triggers the GPCR pathway. The activation of this pathway leads to a series of intracellular reactions, primarily the production of cAMP. This signaling molecule plays a central role in activating downstream effectors, thus propagating the signal initiated by the chemical activators. The downstream effects of these signaling pathways culminate in physiological responses, demonstrating the direct impact these chemical activators have on the functional activity of Olfr458.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $29.00 $58.00 | ||
Heptaldehyde activates Olfr458 by directly binding to its ligand-binding domain. This interaction causes a conformational change in Olfr458, initiating signal transduction through G-protein coupled receptors, leading to increased intracellular cAMP levels and subsequent cellular responses. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
α-Ionone serves as a direct activator of Olfr458 by interacting with its specific odorant binding site. This binding induces allosteric modulation of Olfr458, activating adenylate cyclase via G-protein signaling, thus elevating cAMP and initiating downstream cellular effects. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal directly activates Olfr458 by binding to its ligand-binding domain, triggering a signaling cascade via G-protein activation, leading to the stimulation of adenylate cyclase, increased cAMP levels, and activation of downstream signaling pathways. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
Eucalyptol activates Olfr458 by directly interacting with its ligand-binding site, inducing a conformational change that facilitates the activation of the G-protein coupled receptor pathway, increasing cAMP, and activating subsequent signaling mechanisms. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $40.00 | ||
Geranyl acetate acts as a direct activator of Olfr458 by engaging with its odorant binding site. This interaction prompts a conformational change, activating G-protein signaling cascades, leading to elevated levels of cAMP and activation of downstream cellular pathways. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool activates Olfr458 by binding to its specific odorant receptor site, inducing a structural alteration in the protein. This change triggers G-protein signaling activation, enhancing cAMP production and activating downstream effector molecules. | ||||||
Methyl benzoate | 93-58-3 | sc-215338 sc-215338A | 25 g 500 g | $23.00 $32.00 | ||
Methyl benzoate activates Olfr458 by interacting with its specific odorant binding domain, facilitating the activation of G-protein coupled receptor pathways, increasing cAMP levels, and activating downstream signaling pathways, including protein kinase A activation. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol activates Olfr458 by binding to its specific ligand-binding domain, facilitating the activation of G-protein coupled receptor mechanisms, leading to the elevation of cAMP levels, and triggering a cascade of intracellular signaling pathways and cellular responses. | ||||||