Olfr441 Inhibitors
Olfr441, an integral component of the olfactory system, plays a pivotal role in the initiation of neuronal responses that culminate in the perception of smells. As a member of the G-protein-coupled receptor (GPCR) family, Olfr441 is characterized by a 7-transmembrane domain structure shared with neurotransmitter and hormone receptors. These receptors are encoded by single coding-exon genes, and in the case of Olfr441, they form the largest gene family in the genome. The receptor proteins are involved in recognizing and transducing signals from odorant molecules, facilitating the intricate process of olfactory perception.
The function of Olfr441 revolves around its ability to recognize and bind to odorant molecules, initiating a series of events that lead to the transduction of signals through G protein-mediated pathways. The nomenclature assigned to Olfr441 genes and proteins in this organism is distinct from that of other organisms, underscoring the unique nature of olfactory receptor systems. The receptor's large family size and diversity suggest its crucial role in discriminating and responding to a wide array of odorant stimuli. Inhibition of Olfr441 involves a multifaceted approach, encompassing both direct and indirect mechanisms. The chemicals identified as inhibitors target specific signaling pathways associated with Olfr441 activation. These pathways include cAMP signaling, MAPK signaling, calcium-dependent processes, GPCR internalization, JNK signaling, and the ubiquitin-proteasome system. The intricate interplay of these pathways is crucial for the receptor's proper function in signal recognition and transduction. The identified inhibitors modulate these pathways, either directly interacting with Olfr441 or indirectly influencing its downstream cascades. This disruption hampers the receptor's ability to transduce odorant signals and initiate the neuronal response that leads to smell perception. The inhibition mechanisms highlight the complexity of olfactory signal processing and offer valuable insights into potential avenues for further research in understanding the intricacies of Olfr441 function and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inhibitor targeting the cAMP signaling pathway by blocking the SERCA pump, disrupting the downstream cascade initiated by Olfr441 activation. This disruption hampers G protein-mediated transduction of odorant signals, thereby indirectly inhibiting the olfactory receptor's neuronal response. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Modulator of PKC, influencing the MAPK pathway associated with Olfr441. By altering the phosphorylation status of key components, it indirectly interferes with the transmembrane domain structure shared by olfactory receptors, disrupting their function in signal recognition and transduction. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Calcium channel blocker impacting intracellular calcium concentrations. This indirectly affects Olfr441 by disrupting the calcium-dependent processes involved in the recognition and transduction of odorant signals, thereby inhibiting the olfactory receptor's neuronal response. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibitor of GPCR internalization, specifically targeting the dynamin-dependent endocytic machinery. This indirect inhibition interferes with the normal turnover of olfactory receptors, disrupting their availability on the cell membrane and impairing the recognition and transduction of odorant signals by Olfr441. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Disruptor of the JNK signaling pathway, a downstream target associated with Olfr441 activation. By inhibiting JNK, this chemical indirectly hinders the olfactory receptor's ability to mediate the transduction of odorant signals, impacting the neuronal response triggered by Olfr441. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Interferes with the ubiquitin-proteasome system, disrupting the proteasomal degradation of olfactory receptor proteins. This indirect inhibition results in the accumulation of dysfunctional Olfr441, impairing its function in signal recognition and G protein-mediated transduction of odorant signals. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Modulates the activity of adenylyl cyclase, a key enzyme in the cAMP signaling pathway. This chemical indirectly inhibits Olfr441 by increasing intracellular cAMP levels, disrupting the downstream processes involved in signal transduction and perception of odorants. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Activator of phosphodiesterase, influencing the degradation of cAMP. By regulating cAMP levels, this chemical indirectly interferes with the G protein-mediated transduction of odorant signals initiated by Olfr441, impacting the olfactory receptor's neuronal response and perception of smells. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Interferes with the G protein alpha subunit, disrupting its interaction with Olfr441. This direct inhibition prevents the normal transduction of odorant signals, impairing the olfactory receptor's ability to initiate a neuronal response and perceive smells. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
Modulates the activity of adenylate cyclase, a key player in the cAMP signaling pathway associated with Olfr441. This chemical indirectly inhibits the olfactory receptor by disrupting intracellular cAMP levels, affecting the downstream processes involved in G protein-mediated transduction of odorant signals. | ||||||