Olfr42 Inhibitors
The Olfr42 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, plays a crucial role in initiating neuronal responses essential for perceiving smells. With its 7-transmembrane domain structure, Olfr42 is responsible for the recognition and G protein-mediated transduction of odorant signals. As a key component of the largest olfactory receptor gene family, Olfr42 contributes significantly to the complex landscape of olfactory perception.
The inhibition of Olfr42 involves a sophisticated interplay of direct and indirect mechanisms. Direct inhibitors, such as menthol, isoeugenol, camphor, citronellal, and geraniol, act by binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, including limonene, linalool, eugenol, thymol, vanillin, and carvacrol, modulate the cyclic nucleotide signaling pathway associated with Olfr42. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors offers a comprehensive approach to disrupting Olfr42's role in odor recognition, providing avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr42.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Menthol serves as a direct inhibitor, binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr42. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol functions as a direct inhibitor, binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr42. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr42. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal functions as a direct inhibitor, binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr42. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin serves as a direct inhibitor, binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol functions as a direct inhibitor, binding to Olfr42 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr42. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||