Olfr414 Inhibitors
The Olfr414 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, plays a crucial role in initiating neuronal responses that underlie the perception of smell. Interacting with odorant molecules in the nose, Olfr414, characterized by a 7-transmembrane domain structure shared with neurotransmitter and hormone receptors, facilitates G protein-mediated transduction of odorant signals. As part of the extensive olfactory receptor gene family, Olfr414 significantly contributes to the complexities of olfactory recognition, highlighting its importance in the sensory experience.
Inhibition of Olfr414 involves a sophisticated interplay of direct and indirect mechanisms. Direct inhibitors, including eugenol, 1-octen-3-ol, 2-heptanone, allyl mercaptan, 2,4-dimethylphenol, and 2-methylbutyric acid, act by binding to Olfr414 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as isoborneol, methyl salicylate, terpineol, isoamyl acetate, benzaldehyde, and acetophenone, modulate the cyclic nucleotide signaling pathway associated with Olfr414. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. The diverse array of inhibitors provides a comprehensive approach to disrupting Olfr414's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr414.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol serves as a direct inhibitor by binding to Olfr414, disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isoborneol | 124-76-5 | sc-235391 | 25 g | $28.00 | ||
Isoborneol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr414. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1-Octen-3-ol | 3391-86-4 | sc-237604 | 25 g | $50.00 | ||
1-Octen-3-ol functions as a direct inhibitor by binding to Olfr414, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr414. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone serves as a direct inhibitor by binding to Olfr414, disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr414. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr414. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||