Olfr406 Inhibitors
The Olfr406 olfactory receptor, a member of the G-protein-coupled receptor (GPCR) family, plays a pivotal role in initiating the neuronal response that underlies the perception of smell by interacting with odorant molecules in the nose. Characterized by a 7-transmembrane domain structure, Olfr406 is integral to the G protein-mediated transduction of odorant signals, contributing to the intricate process of olfactory perception. As part of the extensive olfactory receptor gene family, Olfr406 holds significance in the diversity and precision of olfactory recognition.
The inhibition of Olfr406 involves a strategic approach employing both direct and indirect mechanisms. Direct inhibitors, including benzaldehyde, cinnamaldehyde, methyl anthranilate, allyl hexanoate, propionaldehyde, and hexyl acetate, disrupt the receptor's function by binding to it and interfering with the 7-transmembrane domain structure. This interference hampers the receptor's ability to effectively transduce odorant signals through G protein-mediated pathways, leading to the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as limonene, isoamyl acetate, octanal, eugenol, 1,8-cineole, and thymol, target associated signaling pathways, including cAMP and cyclic nucleotides. Their modulation of these pathways leads to altered G protein-mediated transduction of odorant signals, providing an additional layer of inhibition for Olfr406. The diverse array of inhibitors reflects a nuanced strategy to disrupt Olfr406's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirm the efficacy of these inhibitors in practice and further unravel the intricacies of olfactory signal transduction mediated by Olfr406.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dipentene | 138-86-3 | sc-252747 | 4 L | $120.00 | ||
Dipentene acts as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr406. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde functions as a direct inhibitor by binding to Olfr406 and disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate serves as an indirect inhibitor by influencing the cyclic nucleotide signaling pathway linked to Olfr406. Its modulation of this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $25.00 $33.00 | ||
Octanal functions as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr406. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as an indirect inhibitor by influencing the cyclic nucleotide signaling pathway linked to Olfr406. Its modulation of this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
1,8-Cineole serves as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr406. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate acts as a direct inhibitor by binding to Olfr406, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol functions as an indirect inhibitor by influencing the cyclic nucleotide signaling pathway linked to Olfr406. Its modulation of this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||