Olfr390 Inhibitors
Or1e30, a member of the olfactory receptor family 1 subfamily E in Mus musculus (house mouse), is a critical component of the molecular machinery responsible for the perception of smells. Functioning within the nasal cavity, olfactory receptors like Or1e30 interact with odorant molecules, initiating a complex neuronal response that ultimately leads to the recognition of distinct scents. These receptors, characterized by a 7-transmembrane domain structure, belong to the extensive family of G-protein-coupled receptors (GPCRs). The single-coding-exon genes coding for olfactory receptors, including Or1e30, form the largest gene family in the mouse genome. The significance of Or1e30 lies in its ability to recognize and transduce signals from odorant molecules, contributing to the intricate process of olfactory perception in house mice.
The inhibition of Or1e30 involves a nuanced interplay of various chemical compounds, each exerting its influence on the olfactory receptor through direct or indirect mechanisms. Direct inhibitors interfere with the binding of odorant molecules to Or1e30's olfactory receptors, disrupting the normal initiation of neuronal responses. On the other hand, indirect inhibitors modulate specific signaling pathways associated with olfactory signal transduction. These pathways play a crucial role in the transduction of odorant signals, and their alteration by certain chemicals results in an inhibition of Or1e30. The diversity of inhibitory compounds showcases the intricate nature of the olfactory system and the various points at which it can be modulated. This multi-faceted approach to inhibition reflects the complexity of Or1e30's function and the potential for targeted interventions in altering the perception of specific odors in house mice. Understanding the intricate relationship between Or1e30 and its inhibitors provides valuable insights into the molecular mechanisms underlying olfactory perception and opens avenues for further exploration in the field of sensory biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal serves as a direct inhibitor of Or1e30 by interfering with the binding of odorant molecules to the olfactory receptors. This disruption hinders the initiation of a proper neuronal response, leading to a reduced perception of specific odors in the house mouse. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde functions as a direct inhibitor by binding to the olfactory receptors and preventing the proper recognition of odorant molecules. This disruption interferes with the initiation of a neuronal response, impacting the perception of smells associated with Or1e30 in house mice. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol serves as an indirect inhibitor by affecting signaling pathways linked to olfactory receptors. Its influence on these pathways alters the transduction of odorant signals, leading to an inhibition of Or1e30 and a corresponding decrease in the perception of specific odors in mice. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate acts as a direct inhibitor by interfering with the binding of odorant molecules to Or1e30's olfactory receptors. This disruption hampers the initiation of a proper neuronal response, resulting in a diminished perception of specific smells in the house mouse. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate functions as an indirect inhibitor, influencing cellular processes associated with olfactory signal transduction. Its modulation of specific pathways disrupts the normal functioning of Or1e30, impairing the mouse's ability to perceive certain smells through altered neuronal responses. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone acts as a direct inhibitor by binding to the olfactory receptors of Or1e30 and preventing the proper recognition of odorant molecules. This interference disrupts the initiation of a neuronal response, impacting the perception of smells associated with Or1e30 in house mice. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene serves as an indirect inhibitor by modulating signaling pathways linked to olfactory receptors. Its influence on these pathways alters the transduction of odorant signals, leading to an inhibition of Or1e30 and a corresponding decrease in the perception of specific odors in mice. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral acts as a direct inhibitor by interfering with the binding of odorant molecules to Or1e30's olfactory receptors. This disruption hampers the initiation of a proper neuronal response, resulting in a diminished perception of specific smells in the house mouse. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Allyl isothiocyanate functions as an indirect inhibitor by affecting cellular processes associated with olfactory signal transduction. Its modulation of specific pathways disrupts the normal functioning of Or1e30, impairing the mouse's ability to perceive certain smells through altered neuronal responses. | ||||||