Olfr378 Inhibitors
Or1e19, a prominent member of the olfactory receptor family 1 subfamily E in Mus musculus (house mouse), plays a pivotal role in the intricate process of odor perception. Functioning as a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Or1e19 is integral to the initiation of neuronal responses triggered by the interaction with odorant molecules in the nose. As part of the expansive olfactory receptor gene family, Or1e19 contributes significantly to the remarkable diversity of GPCRs dedicated to recognizing and transducing odorant signals. This family, characterized by single coding-exon genes, is paramount in the genomic landscape, underscoring the importance of olfactory receptors in the sensory realm.
The general mechanisms of inhibiting Or1e19 involve targeting specific cellular pathways crucial for GPCR-mediated transduction of odorant signals. Various inhibitors disrupt the normal functioning of Or1e19, hindering its ability to initiate neuronal responses in the presence of odorant molecules. These inhibitors act through direct and indirect means, impacting diverse pathways such as histamine receptors, GABA-A receptors, sodium channels, PI3-kinase, histone deacetylases, dopamine receptors, PLC, cyclooxygenase, and TRPV1 receptors. By intervening in these intricate cellular processes, the inhibitors impair the transduction of odorant signals, ultimately impeding the initiation of neuronal responses associated with Or1e19. This comprehensive understanding of the molecular interactions and pathways involved in Or1e19's function and inhibition contributes valuable insights into the complex mechanisms underlying olfactory perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $52.00 $84.00 $124.00 | 4 | |
Diphenhydramine is a direct inhibitor of Or1e19, blocking histamine receptors. This interference disrupts GPCR-mediated transduction of odorant signals, impairing the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a direct inhibitor of Or1e19, blocking sodium channels and hindering GPCR-mediated transduction. This interference impairs the initiation of neuronal responses to odorant molecules in the nose by disrupting the transduction of odorant signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin directly inhibits Or1e19 by targeting PI3-kinase and disrupting downstream signaling pathways. This interference inhibits GPCR-mediated transduction of odorant signals, impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A acts as a direct inhibitor of Or1e19 by inhibiting histone deacetylases. This interference disrupts GPCR-mediated transduction of odorant signals, impairing the initiation of neuronal responses to odorant molecules in the nose. | ||||||
SCH 23390 | 125941-87-9 | sc-200408 sc-200408A | 5 mg 25 mg | $179.00 $733.00 | 2 | |
SCH-23390 indirectly inhibits Or1e19 by blocking dopamine receptors. This modulation influences intracellular cAMP levels, disrupting the cAMP signaling pathway and impeding neuronal responses to odorant molecules in the nose. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin is a direct inhibitor of Or1e19, inhibiting cyclooxygenase and disrupting the prostaglandin pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 directly inhibits Or1e19, targeting PI3-kinase and disrupting downstream signaling pathways. This interference inhibits GPCR-mediated transduction of odorant signals, impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capsazepine indirectly inhibits Or1e19 by blocking TRPV1 receptors. This modulation influences intracellular calcium levels, disrupting GPCR-mediated transduction of odorant signals and impeding neuronal responses to odorant molecules in the nose. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM indirectly inhibits Or1e19 by chelating intracellular calcium. This modulation influences GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of calcium-dependent processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 directly interferes with Or1e19 by inhibiting MEK and disrupting the MAPK pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of the MAPK pathway. | ||||||