Olfr376 Inhibitors

Or1e1c, a member of the olfactory receptor family 1 subfamily E in Mus musculus (house mouse), plays a crucial role in the initiation of neuronal responses, contributing to the perception of smells. Olfactory receptors, including Or1e1c, belong to the G-protein-coupled receptor (GPCR) family and share a 7-transmembrane domain structure with neurotransmitter and hormone receptors. This extensive family represents the largest gene family in the genome, underscoring the importance of olfactory receptors in sensory perception. The inhibition of Or1e1c involves various chemicals targeting specific pathways. Ranitidine, a histamine receptor blocker, directly impedes Or1e1c by disrupting GPCR-mediated transduction. Muscimol indirectly inhibits Or1e1c by modulating intracellular chloride levels through GABA-A receptor activation. Lidocaine is a direct inhibitor of Or1e1c, blocking sodium channels and hindering GPCR-mediated transduction. Wortmannin directly inhibits Or1e1c by targeting PI3-kinase and disrupting downstream signaling pathways. Oxamflatin acts as a direct inhibitor by inhibiting histone deacetylases, disrupting GPCR-mediated transduction.

SCH-23390 indirectly inhibits Or1e1c by blocking dopamine receptors, influencing cAMP levels. U73122 directly inhibits Or1e1c by inhibiting PLC, disrupting downstream signaling pathways. Ibuprofen is a direct inhibitor, inhibiting cyclooxygenase and disrupting the prostaglandin pathway. LY294002 directly inhibits Or1e1c by targeting PI3-kinase and disrupting downstream signaling pathways. Capsazepine indirectly inhibits Or1e1c by blocking TRPV1 receptors, influencing intracellular calcium levels. BAPTA-AM indirectly inhibits Or1e1c by chelating intracellular calcium, hindering GPCR-mediated transduction. PD98059 directly interferes with Or1e1c by inhibiting MEK and disrupting the MAPK pathway. The general mechanisms of inhibition involve the disruption of key signaling pathways crucial for GPCR-mediated transduction, ultimately impairing the initiation of neuronal responses to odorant molecules in the nose. These findings contribute to a deeper understanding of the intricate processes involved in olfactory receptor function, shedding light on potential avenues for further exploration in sensory biology.