Olfr356 Inhibitors
Inhibitors of Olfr356 operate through diverse molecular interactions and signaling mechanisms that ultimately suppress the receptor's functional activity. Certain inhibitors achieve this by modulating secondary messenger concentrations within olfactory neurons. The accumulation of specific cyclic nucleotides leads to the activation of kinases that phosphorylate the receptor, thereby reducing its sensitivity to odorants. Other inhibitors exert their influence by binding directly to Olfr356 or its associated ion channels, altering the receptor's conformation and preventing the initiation of signal transduction. Moreover, the application of specific metal ions can result in the stabilization of the receptor in an inactive state or interfere with the receptor's ability to interact with its signaling partners, thus inhibiting its activity.
In addition to direct receptor interaction, some inhibitors indirectly diminish Olfr356 function by modifying neuronal excitability and neurotransmitter release, which are critical for the receptor's signaling capabilities. For example, the blockade of voltage-gated sodium channels by local anesthetics can lead to reduced neuronal firing and, consequently, a decrease in receptor signaling. Other inhibitors affect intracellular signaling pathways by altering levels of molecules that regulate these pathways, leading to a diminished receptor response. Furthermore, antagonists of specific receptors can modulate the intracellular signaling environment, indirectly leading to the suppression of Olfr356 activity by affecting the downstream signaling cascade associated with this olfactory receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
This cyclic nucleotide serves as a secondary messenger that can downregulate the activity of Olfr356 by altering the intracellular signaling cascade. Elevated levels of cAMP lead to the activation of protein kinase A (PKA), which can phosphorylate and desensitize the olfactory receptors, thereby reducing their response to odorants. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions are known to bind to and block olfactory receptors. For Olfr356, the binding of copper ions can lead to conformational changes that prevent odorant binding and subsequent signal transduction, effectively inhibiting its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as allosteric inhibitors of olfactory receptors. By binding to distinct sites, they can inhibit the functional activity of Olfr356 by stabilizing inactive conformations of the receptor or by interfering with the receptor's ability to interact with signal transduction components. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
A bitter compound that has been shown to modulate G-protein coupled receptor activity. Through competitive binding or allosteric modulation, quinine can decrease the sensitivity and activity of Olfr356 by altering its conformation or the conformation of its associated G-proteins. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Known to stimulate vanilloid receptors, capsaicin indirectly affects the activity of Olfr356 by inducing calcium influx into olfactory sensory neurons. This influx can desensitize and decrease the responsiveness of olfactory receptors to their specific odorants. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
This compound is capable of modulating various G-protein coupled receptors. Chloroquine can inhibit Olfr356 by binding to the receptor's ligand-binding domain, preventing the interaction with its specific odorant molecules and subsequent signal transduction. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Can inhibit voltage-gated sodium channels, which are critical for action potential generation in neurons. This inhibition can lead to a reduction in the neuronal activity of olfactory receptor neurons expressing Olfr356, thereby decreasing its functional signaling. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
This polycationic dye can block calcium channels, thus indirectly affecting the activity of Olfr356 by preventing calcium-mediated signaling events within olfactory sensory neurons, which is crucial for the receptor's signal transduction. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
That can modulate G-protein coupled receptor function. By altering prostaglandin levels, ibuprofen can influence the intracellular signaling pathways linked to Olfr356, leading to reduced receptor activity. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $72.00 $160.00 | 15 | |
A selective cannabinoid receptor antagonist that can influence various G-protein coupled receptors. Rimonabant can inhibit the activity of Olfr356 by altering the intracellular signaling milieu, specifically by modulating the levels of cAMP and affecting the downstream signaling cascade. | ||||||