Olfr331 Inhibitors
Inhibitors of the Olfr331 protein operate through a variety of pathways, ultimately leading to a reduction in the functional activity of this olfactory receptor. Some inhibitors, such as metallic salts, function by directly interfering with the receptor-ligand interaction at the olfactory receptor level. These salts can bind to the odorant binding sites, thus blocking the interaction between the receptor and its specific odorants, which prevents the initiation of olfactory signal transduction. Others, including certain pharmaceutical compounds, can influence signaling cascades indirectly associated with olfactory perception. For instance, antagonists that target neurotransmitter systems can affect the neural circuits within the olfactory bulb, consequently modulating the activation of the receptor. Additionally, compounds that alter intracellular second messengers or ion concentrations, such as cAMP or calcium, can also reduce the sensitivity and downstream signaling of the receptor by affecting the receptor's ability to respond to odorant binding.
Furthermore, inhibitors that target ion channels and transporters within olfactory sensory neurons can indirectly diminish the activity of Olfr331. By altering the neuronal excitability or disrupting ion gradients essential for olfactory signal transduction, these inhibitors can lead to a decrease in receptor activity. Compounds that interfere with cellular processes such as endocytosis or energy production could also indirectly affect the cell surface expression or the overall functionality of the receptor. In addition, certain cooling agents and taste receptor antagonists may inhibit Olfr331 by competing sensory inputs, such as the sensation of cold or bitterness, which can override or diminish the perception of odors, thus affecting the overall responsiveness of the receptor.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
A cooling agent that activates the TRPM8 channel which can indirectly inhibit the Olfr331 by overriding the perception of olfactory stimuli with sensations of cold, thus modulating the perceived intensity and quality of odors detected by Olfr331. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
A vanilloid receptor antagonist that blocks TRPV1, which has a modulatory role on olfactory neurons. By inhibiting TRPV1, capsazepine may reduce the activity of neurons expressing Olfr331, leading to decreased sensitivity to specific odorants. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
A dopamine receptor antagonist known to affect the cAMP pathway. Since olfactory signal transduction involves cAMP as a second messenger, thioridazine could reduce the sensitivity of Olfr331 by altering cAMP levels in olfactory sensory neurons. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
A compound that can bind to and block odorant binding sites on olfactory receptors, such as Olfr331, thus preventing odorant-receptor interactions and inhibiting the activation of the receptor. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
An inhibitor of several ion channels including calcium channels. By blocking calcium influx, it may indirectly inhibit the function of Olfr331, as calcium is crucial for olfactory signal transduction. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Can bind to olfactory receptors and inhibit their function. Its binding to Olfr331 could block odorant interaction and receptor activation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to alkalinize intracellular vesicles and disrupt endosomal function. If Olfr331 undergoes internalization and recycling through endosomes, chloroquine could inhibit this process and reduce the receptor's cell surface expression. | ||||||
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $51.00 $82.00 $122.00 | 4 | |
Although its primary action is on histamine receptors, it might affect olfactory receptor neurons expressing Olfr331 by altering neurotransmitter levels in the olfactory bulb. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
A known bitter taste receptor antagonist that might influence olfactory perception by modulating the taste-smell integration process, indirectly affecting the functional activity of Olfr331 in olfactory sensory neurons. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
A GABA-A receptor antagonist that can influence neuronal excitability. In the olfactory system, it might alter the signaling cascades, leading to decreased activity of olfactory receptors including Olfr331. | ||||||