Olfr331 Activators
Chemical activators of Olfr331 can initiate a complex series of molecular events leading to the activation of olfactory sensory neurons. Benzaldehyde, for instance, binds to the ligand-binding site of Olfr331, inducing a structural alteration that triggers the receptor. This interaction sets off a signal transduction pathway characteristic of G-protein-coupled receptors. Similarly, isoamyl acetate serves as another agonist for Olfr331, and upon its binding, it activates a G-protein-mediated response that escalates cyclic AMP levels within the cell. This elevation in cAMP activates protein kinase A (PKA), which then leads to the phosphorylation of channels and neuronal excitation. Another ligand, octanal, also docks on Olfr331 and its binding promotes a conformational change that activates the receptor, leading to the production of second messengers and activation of downstream effectors, resulting in a detectable neuronal response.
Furthermore, 2-Nonanone engages with Olfr331 by fitting into its ligand-binding domain, which prompts a conformational shift and subsequent activation of the G-protein signaling cascade, resulting in the opening of ion channels. Heptanal and decanal function similarly as agonists to Olfr331, with their binding enhancing intracellular cAMP, which activates ion channels and generates a neural response. Citronellal, acetophenone, and methyl salicylate activate Olfr331 through their interaction with the ligand-binding site, leading to a signaling cascade that elevates intracellular cAMP and activates PKA. This cascade results in the opening of ion channels, changing the membrane potential, and eliciting a neural response. Ethyl butyrate, propyl benzoate, and anisaldehyde also activate Olfr331 by binding to the receptor's ligand-binding site and triggering a G-protein-coupled signaling cascade, causing an increase in cAMP levels and leading to the activation of ion channels and sensory neuron depolarization. Each chemical, while diverse in structure, converges on the same pathway to activate Olfr331, illustrating the receptor's role in detecting a wide range of odorant molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate serves as a ligand for Olfr331. Upon binding, it activates the receptor, which triggers a G-protein-coupled response, leading to an increase in cyclic AMP levels and subsequent activation of protein kinase A. This phosphorylation cascade ultimately results in the opening of ion channels and neuronal firing. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal binds directly to Olfr331, initiating its activation. This binding promotes a change in receptor conformation, triggering a G-protein-coupled signal transduction pathway that leads to the production of second messengers and activation of downstream effectors, culminating in an excitatory response in olfactory sensory neurons. | ||||||
2-Nonanone | 821-55-6 | sc-238184 sc-238184A | 5 g 100 g | $47.00 $84.00 | ||
2-Nonanone activates Olfr331 by binding to its specific ligand-binding domain, which causes a conformational shift in the receptor's structure. This shift facilitates the coupling with G-proteins and the subsequent production of cyclic AMP, which then activates a cascade of kinases, culminating in the opening of ion channels and cellular response. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal, as a ligand for Olfr331, binds to the receptor and activates it through the associated G-protein signaling pathway. This activation leads to an increase in intracellular calcium via the cAMP pathway, which in turn causes a series of downstream effects, resulting in excitation of the olfactory sensory neurons. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal functions as an agonist for Olfr331, binding to the receptor and activating it. The activation of Olfr331 by Decanal triggers a G-protein-coupled response that increases intracellular cAMP, leading to the activation of the ion channels and a neural response. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal activates Olfr331 by molecular interaction with the receptor's ligand-binding region, initiating a signaling cascade through G-protein activation that elevates intracellular cAMP. This activation results in the opening of ion channels and neuronal excitation specific to the olfactory signal transduction pathway. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone activates Olfr331 by docking at the receptor's ligand-binding site, which induces a structural change in the receptor leading to the activation of its G-protein-coupled signaling mechanism. This results in the production of cAMP, which activates protein kinase A and leads to the opening of cyclic nucleotide-gated ion channels, generating a neural signal. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates Olfr331 through its interaction with the ligand-binding site of the receptor, facilitating a G-protein-coupled signaling cascade. This cascade increases cAMP levels within the cell, activating protein kinase A, which in turn leads to the opening of ion channels and a change in the membrane potential, triggering a neural response. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate binds to and activates Olfr331, initiating a signal transduction pathway via G-protein-coupled receptor activation. The rise in cAMP levels following this activation leads to the phosphorylation of specific proteins and the opening of ion channels, thereby generating an olfactory sensory signal. | ||||||