OAS1 Activators
OAS1, or 2'-5'-oligoadenylate synthetase 1, is a crucial component of the innate immune response, particularly in defense against viral infections. This protein belongs to the OAS family, members of which are activated upon detection of viral nucleic acids, particularly double-stranded RNA (dsRNA), a common intermediate in viral replication. Upon viral infection, OAS1 is activated through its interaction with dsRNA, leading to its enzymatic activity. Once activated, OAS1 catalyzes the synthesis of 2'-5'-oligoadenylates (2-5As) from ATP, which in turn activate RNase L, an endoribonuclease responsible for degrading viral RNA and inhibiting viral replication. Thus, OAS1 serves as a critical component of the antiviral defense mechanism, acting as an early responder to viral infections and triggering a cascade of events aimed at restricting viral spread within host cells.
Activation of OAS1 is predominantly mediated by its interaction with viral nucleic acids, particularly dsRNA, which serves as a potent activator of OAS1 enzymatic activity. Upon binding to dsRNA, OAS1 undergoes a conformational change that enhances its catalytic activity, leading to the synthesis of 2-5As. Additionally, cellular factors such as protein kinase R (PKR) and interferon-induced proteins may contribute to the activation of OAS1, amplifying the antiviral response initiated by OAS1 activation. Furthermore, OAS1 activation is tightly regulated to prevent aberrant activation and cellular damage. Understanding the mechanisms underlying OAS1 activation provides insights into the innate immune response to viral infections and offers targets for interventions aimed at bolstering antiviral defense mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amlexanox | 68302-57-8 | sc-217630 | 10 mg | $160.00 | 2 | |
Amlexanox, a small molecule, activates OAS1 by inhibiting IKKε/TBK1, leading to the enhanced expression and activation of OAS1. This compound, through its interference with the IKKε/TBK1 pathway, boosts the transcription of OAS1 and promotes its enzymatic activity in the cellular antiviral response. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib, a Janus kinase (JAK) inhibitor, indirectly activates OAS1 by modulating the JAK-STAT pathway. By inhibiting JAK1 and JAK2, Ruxolitinib influences downstream signaling, including OAS1 activation, in response to interferons. This pharmacological action enhances the expression and function of OAS1 in antiviral defense mechanisms. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod, a toll-like receptor 7 (TLR7) agonist, activates OAS1 by engaging the TLR7-mediated signaling cascade. Upon TLR7 stimulation, downstream pathways are activated, leading to increased OAS1 expression and activity. Imiquimod, by mimicking viral RNA, effectively triggers OAS1-dependent antiviral responses through the TLR7 pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates OAS1 by modulating the p38 MAPK pathway. Through inhibition of p38 MAPK, SB203580 relieves negative feedback on OAS1, resulting in increased OAS1 expression and activity. This compound highlights the intricate interplay between p38 MAPK signaling and OAS1 activation, offering a route for indirect activation of OAS1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, activates OAS1 by influencing the SIRT1/AMPK pathway. By activating SIRT1 and subsequently AMPK, Resveratrol enhances OAS1 expression and activity. This compound exemplifies how cellular energy sensing pathways can cross-talk with OAS1 regulation, providing a unique avenue for the modulation of OAS1 function. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
Nordihydroguaiaretic Acid, an antioxidant, indirectly activates OAS1 by inhibiting the NF-κB pathway. Through suppression of NF-κB, this compound relieves transcriptional repression on OAS1, leading to increased OAS1 expression and activity. Nordihydroguaiaretic Acid highlights the connection between oxidative stress signaling and OAS1 activation, offering a distinct regulatory mechanism. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, activates OAS1 by demethylating its promoter region. By reducing DNA methylation, this compound promotes transcriptional activation of OAS1, leading to increased expression and enzymatic activity. 5-Aza-2'-deoxycytidine demonstrates the epigenetic regulation of OAS1, providing insights into the modulation of OAS1 expression. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a component of the outer membrane of Gram-negative bacteria, activates OAS1 by engaging toll-like receptor 4 (TLR4) signaling. Through TLR4 activation, downstream pathways lead to increased OAS1 expression and activity. LPS serves as a molecular trigger, mimicking bacterial infection, and effectively inducing OAS1-mediated antiviral responses. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMP-activated protein kinase (AMPK) activator, indirectly activates OAS1 by modulating the AMPK pathway. Through AMPK activation, A769662 enhances OAS1 expression and activity, underscoring the regulatory crosstalk between cellular energy sensing and antiviral defense mechanisms. A769662 provides a pharmacological avenue for OAS1 activation through AMPK modulation. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal, an eIF2α dephosphorylation inhibitor, activates OAS1 by influencing the integrated stress response. By preventing eIF2α dephosphorylation, Salubrinal promotes downstream signaling that culminates in increased OAS1 expression and activity. This compound exemplifies how cellular stress responses can intricately regulate OAS1 function, offering a unique avenue for activation. | ||||||