Nurr1 Activators
The chemical class of Nurr1 activators comprises a diverse group of compounds that can modulate the activity of the nuclear receptor related 1 protein (Nurr1). Nurr1 is a transcription factor belonging to the nuclear receptor superfamily and plays a pivotal role in the development and maintenance of dopaminergic neurons. While direct activators of Nurr1 are less commonly identified, several compounds indirectly impact Nurr1 activation through diverse cellular pathways. Norharmane, a beta-carboline alkaloid, indirectly activates Nurr1 by acting as a ligand for the aryl hydrocarbon receptor (AhR). AhR activation by norharmane suggests crosstalk between AhR-regulated pathways and Nurr1 function. MPTP, a prodrug metabolized to MPP+ in the brain, indirectly activates Nurr1 by disrupting mitochondrial function and inducing oxidative stress. This oxidative stress triggers signaling cascades that impact Nurr1 activity, suggesting a link between mitochondrial dysfunction, oxidative stress, and Nurr1-mediated transcriptional regulation. Quercetin, a flavonoid with antioxidant properties, indirectly activates Nurr1 by modulating cellular redox status. The interplay between quercetin, reactive oxygen species (ROS), and Nurr1 suggests a role for this natural compound in redox-sensitive pathways that influence Nurr1-mediated transcriptional regulation in neuronal cells.
Berberine, an isoquinoline alkaloid with antioxidant and anti-inflammatory properties, indirectly activates Nurr1 by modulating pathways involved in oxidative stress and inflammation. Apigenin, a flavonoid found in parsley and chamomile tea, indirectly activates Nurr1 through its antioxidant and anti-inflammatory properties. The intricate relationship between apigenin, oxidative stress, and Nurr1 suggests a role for this natural compound in modulating Nurr1-mediated transcriptional regulation within the context of cellular stress and inflammation. CDDO-Imidazolide, a synthetic triterpenoid that activates Nrf2, indirectly impacts Nurr1 activation by modulating cellular redox status and antioxidant pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 0742 | 317318-84-6 | sc-203991 sc-203991A | 10 mg 50 mg | $194.00 $831.00 | 11 | |
Selective PPARβ/δ agonist that indirectly influences Nurr1 activation through cross-talk between PPARβ/δ and Nurr1-regulated pathways, highlighting the interconnectedness of nuclear receptor signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Indirectly activates Nurr1 by modulating cellular redox status through its antioxidant properties, suggesting a potential role in redox-sensitive pathways that influence Nurr1-mediated transcriptional regulation in neuronal cells. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Ion channel blocker that indirectly activates Nurr1 by modulating ion channel activity, providing insights into the regulatory mechanisms linking ion homeostasis and Nurr1 function. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Flavonol with antioxidant and anti-inflammatory properties, indirectly activates Nurr1 by impacting cellular redox status and inflammatory signaling, suggesting a potential role in modulating Nurr1-mediated transcriptional regulation within the context of cellular stress and inflammation. | ||||||
3,4-Dihydroxyphenyl Ethanol | 10597-60-1 | sc-202887 | 10 mg | $112.00 | 6 | |
Polyphenol that indirectly activates Nurr1 through its antioxidant properties, indicating a potential role in influencing Nurr1-mediated transcriptional regulation within the context of cellular oxidative stress and redox-sensitive pathways. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
Selective PPARδ agonist that indirectly influences Nurr1 activation through cross-talk between PPARδ and Nurr1-regulated pathways, warranting further exploration of the intricate network of signaling events. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Isoquinoline alkaloid with antioxidant and anti-inflammatory properties, indirectly activates Nurr1 by modulating pathways involved in oxidative stress and inflammation, suggesting a potential role in influencing Nurr1-mediated transcriptional regulation within the context of cellular stress and inflammation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Flavonoid with antioxidant and anti-inflammatory properties, indirectly activates Nurr1 by impacting cellular redox status and inflammatory signaling, suggesting a potential role in modulating Nurr1-mediated transcriptional regulation within the context of cellular stress and inflammation. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
Synthetic triterpenoid that indirectly impacts Nurr1 activation by activating Nrf2 and modulating cellular redox status and antioxidant pathways, suggesting a potential role in influencing Nurr1-mediated transcriptional regulation within the context of cellular oxidative stress. | ||||||