Nup62CL Activators
Activators of Nup62CL function by influencing diverse cellular signaling pathways, ultimately affecting the protein's role in nucleocytoplasmic transport. For instance, certain activators can directly stimulate adenylyl cyclase, resulting in an elevation of cAMP levels within the cell. This surge in cAMP activates protein kinase A (PKA), which may phosphorylate various proteins involved in the nuclear pore complex, enhancing the transport functions associated with Nup62CL. Other activators work by modulating calcium concentrations inside the cell, either through acting as calcium ionophores or by disrupting intracellular calcium stores. The resultant increase in intracellular calcium can alter the phosphorylation state of proteins by activating calcium-dependent kinases or inhibiting phosphatases, thereby indirectly affecting Nup62CL's activity within the nuclear transport mechanism.
Furthermore, there are compounds known to inhibit protein phosphatases, leading to an accumulation of phosphorylated proteins, which could subsequently enhance the functional activity of Nup62CL in the nuclear pore complexes. Some activators are known to affect gene expression patterns through inhibition of DNA methyltransferases, altering the landscape of protein interactions and possibly influencing Nup62CL's nuclear transport role. Additionally, the inhibition of specific kinases can sometimes lead to compensatory cellular responses that increase the activity of alternative pathways and kinases. These compensatory mechanisms may inadvertently elevate the activity of kinases responsible for phosphorylating components of the nuclear pore complex, thereby potentially increasing the activity of Nup62CL.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that acts as a potent activator of protein kinase C, which can phosphorylate proteins involved in nucleocytoplasmic transport affecting Nup62CL activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, potentially modifying the phosphorylation state of proteins and thereby influencing Nup62CL-mediated nuclear transport. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cAMP analog that is resistant to degradation by phosphodiesterases, thus persistently activating PKA and potentially enhancing Nup62CL activity in its role in nucleocytoplasmic exchange. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation of cellular proteins that could enhance the functional activity of Nup62CL in nuclear pore complexes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea that has been shown to inhibit DNA methyltransferases, potentially affecting gene expression patterns and indirectly influencing Nup62CL function in nuclear transport. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
An inhibitor of protein phosphatases similar to okadaic acid, which may indirectly lead to an increase in the phosphorylation state of nuclear transport machinery, thereby activating Nup62CL. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A non-selective protein kinase inhibitor that, through complex kinase interplay, may indirectly increase the activity of kinases that phosphorylate proteins in the nuclear pore complex, potentially increasing Nup62CL activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A sesquiterpene lactone that disrupts calcium stores and could influence calcium-dependent signaling pathways, potentially affecting Nup62CL's role in nucleocytoplasmic transport. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore, which increases intracellular calcium levels and could modify signaling pathways that indirectly activate Nup62CL's function in nuclear transport. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A specific inhibitor of protein kinase C that may lead to compensatory cellular responses, potentially enhancing the activity of other kinases that phosphorylate components of the nuclear pore, including Nup62CL. | ||||||