NRAMP 2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
Deferoxamine is an iron chelator that indirectly inhibits NRAMP 2 by sequestering iron ions. Iron is an essential cofactor for NRAMP 2 activity, and its chelation interferes with NRAMP 2's iron transport function, thereby inhibiting its role in iron homeostasis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly inhibits NRAMP 2 by modulating the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by Resveratrol can lead to increased expression of heme oxygenase-1 (HO-1), which can negatively regulate NRAMP 2 expression, thereby inhibiting its function in iron transport. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can indirectly inhibit NRAMP 2 by influencing the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by Quercetin can enhance the expression of HO-1, which in turn can negatively regulate NRAMP 2 expression, leading to its inhibition in iron transport. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic Acid indirectly inhibits NRAMP 2 through its antioxidative properties. By reducing oxidative stress, Alpha-Lipoic Acid can attenuate NRAMP 2-related iron uptake processes, thereby inhibiting its function in iron transport. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine indirectly inhibits NRAMP 2 by activating AMP-activated protein kinase (AMPK). AMPK activation can negatively regulate NRAMP 2 expression, thereby inhibiting its role in iron transport through modulation of cellular energy metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly inhibits NRAMP 2 by affecting the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by Curcumin can result in increased HO-1 expression, which can negatively regulate NRAMP 2 expression, leading to inhibition of its iron transport function. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin indirectly inhibits NRAMP 2 through its influence on the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by Apigenin can enhance HO-1 expression, which in turn negatively regulates NRAMP 2 expression, leading to inhibition of iron transport. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium Arsenite indirectly inhibits NRAMP 2 by inducing oxidative stress. Increased oxidative stress can negatively impact NRAMP 2's iron transport function, thereby inhibiting its role in cellular iron homeostasis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane indirectly inhibits NRAMP 2 through its activation of the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by Sulforaphane can lead to increased HO-1 expression, which negatively regulates NRAMP 2 expression, inhibiting its iron transport function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG indirectly inhibits NRAMP 2 by influencing the Nrf2-Keap1 signaling pathway. Activation of Nrf2 by EGCG can enhance HO-1 expression, which can negatively regulate NRAMP 2 expression, leading to inhibition of its role in iron transport. | ||||||