NPIPL2 inhibitors are a class of chemical compounds designed to modulate the activity of the NPIPL2 protein. NPIPL2, short for Nuclear Pore Complex Interacting Protein-Like 2, is part of a larger family of proteins involved in regulating various intracellular processes. These processes can include protein trafficking, cellular signaling pathways, and the maintenance of nuclear-cytoplasmic transport. NPIPL2 itself has a particular role in interactions related to the nuclear pore complex (NPC), a key cellular structure responsible for the regulated exchange of molecules between the nucleus and the cytoplasm. By inhibiting NPIPL2 function, compounds classified as NPIPL2 inhibitors can disrupt or modulate its associated pathways, affecting cellular homeostasis and potentially altering the balance of molecular transport across the nuclear envelope. This mode of action is crucial to understanding the broader cellular implications of these inhibitors and how they can influence the dynamics of protein and RNA movement within cells.
Structurally, NPIPL2 inhibitors can vary significantly but often contain functional groups capable of interacting with the active or binding sites of the NPIPL2 protein. This interaction can occur through covalent or non-covalent mechanisms, which may include hydrogen bonding, hydrophobic interactions, and van der Waals forces. The specificity and affinity of an NPIPL2 inhibitor for its target protein are influenced by its molecular architecture, which is optimized to ensure effective binding while minimizing off-target effects on other proteins. As such, the development and study of NPIPL2 inhibitors require careful examination of both their chemical structure and their binding dynamics with NPIPL2. These inhibitors are of great interest for research into cellular processes controlled by nuclear transport and are used to study the role of NPIPL2 in different cellular contexts, particularly how its inhibition may alter cellular behavior or phenotype.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphoinositide 3-kinase (PI3K) inhibitor that can affect the PI3K/AKT signaling pathway, potentially altering the function of proteins regulated by this pathway, including possibly NPIPL2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A MEK inhibitor that can interfere with the MAPK/ERK pathway, potentially affecting the function and regulation of proteins involved in this pathway, which may include NPIPL2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor that can prevent the activation of AKT, potentially affecting proteins regulated by the PI3K/AKT pathway, including possibly NPIPL2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that can block the p38 pathway, potentially affecting proteins that are regulated by stress-activated signaling, which may include NPIPL2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can suppress the mTOR signaling pathway, potentially affecting the function of proteins involved in cell growth and proliferation, including possibly NPIPL2. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of proteins, potentially affecting the levels of NPIPL2 if it is regulated by proteasomal degradation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which can affect proteins regulated by JNK signaling, potentially including NPIPL2. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Another proteasome inhibitor that can lead to the accumulation of proteins that are normally degraded by the proteasome, potentially affecting the stability and function of NPIPL2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which can block the activation of ERK, potentially affecting proteins that are part of the MAPK/ERK pathway, possibly including NPIPL2. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $67.00 $539.00 | ||
A compound that can inhibit the activation of NF-κB, potentially affecting proteins regulated by NF-κB signaling, which may include NPIPL2. | ||||||