Notch 3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT inhibits γ-secretase, a key enzyme in the Notch signaling pathway. By blocking the cleavage of Notch, DAPT prevents the release of the active Notch intracellular domain, thus directly inhibiting Notch 3 activation. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $235.00 $260.00 | 4 | |
DBZ inhibits γ-secretase, disrupting Notch signaling. By impeding Notch 3 cleavage and release of its intracellular domain, DBZ serves as a direct inhibitor of Notch 3 activation, influencing its downstream transcriptional effects. | ||||||
SAHM1 | 2050906-89-1 | sc-507534 | 5 mg | $1435.00 | ||
SAHM1 is a selective inhibitor of Mastermind-like (MAML) proteins, essential co-activators in Notch signaling. By targeting MAML, SAHM1 indirectly modulates Notch 3 activity, impacting its transcriptional regulation within the signaling cascade. | ||||||
FLI-06 | 313967-18-9 | sc-497529 | 5 mg | $82.00 | ||
FLI-06 interferes with the Notch transcriptional complex by disrupting the interaction between Notch and its co-activator, Mastermind. This direct inhibition alters Notch 3's ability to regulate gene expression, influencing downstream cellular responses. | ||||||
LY411575 | 209984-57-6 | sc-364529 sc-364529A | 10 mg 50 mg | $198.00 $473.00 | 6 | |
LY-411575 is a γ-secretase inhibitor, blocking the cleavage of Notch receptors. Through direct inhibition of Notch activation, LY-411575 modulates Notch 3 signaling, affecting its downstream transcriptional functions within various cellular contexts. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $439.00 $1417.00 | 1 | |
RO4929097 is a γ-secretase inhibitor that directly targets Notch signaling. By preventing Notch 3 activation, RO4929097 interferes with the release of the intracellular domain, influencing downstream transcriptional responses in cells dependent on Notch signaling. | ||||||
MK-0752 | 471905-41-6 | sc-364534 sc-364534A | 10 mg 50 mg | $592.00 $1550.00 | ||
MK-0752 is a γ-secretase inhibitor that directly blocks Notch activation. By inhibiting cleavage and release of the Notch intracellular domain, MK-0752 serves as a direct inhibitor of Notch 3, modulating its downstream transcriptional effects in various cellular contexts. | ||||||
L-685,458 | 292632-98-5 | sc-204042 sc-204042A | 1 mg 5 mg | $337.00 $1000.00 | 4 | |
L685,458 is a γ-secretase inhibitor, blocking Notch receptor cleavage. This direct inhibition of Notch activation impacts Notch 3 signaling, influencing its downstream transcriptional effects in a variety of cellular processes dependent on Notch signaling. | ||||||
Compound E | 209986-17-4 | sc-221433 sc-221433A sc-221433B | 250 µg 1 mg 5 mg | $124.00 $342.00 $967.00 | 12 | |
Compound E is a γ-secretase inhibitor that directly inhibits Notch signaling. Through blocking cleavage and release of the Notch intracellular domain, Compound E directly influences Notch 3, altering its downstream transcriptional effects in various cellular contexts. | ||||||