NOS3 Inhibitors
Santa Cruz Biotechnology now offers a broad range of NOS3 Inhibitors. Nitric oxide (NO) has a broad range of biological activities including cell signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS3 (also designated ecNOS), is a constitutive Ca2+/CaM-dependent form of NOS, which was first identified in endothelial cells. NOS3 Inhibitors offered by Santa Cruz inhibit NOS3 and, in some cases, other cell signaling and nitric oxide synthesis related proteins. View detailed NOS3 Inhibitor specifications, including NOS3 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 31 to 35 of 35 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
S-Methyl-L-thiocitrulline acetate salt | 174063-92-4 | sc-215830 sc-215830A | 10 mg 50 mg | $89.00 $287.00 | 2 | |
S-Methyl-L-thiocitrulline acetate salt engages with NOS3 through its thiol group, which can form reversible covalent bonds, influencing enzyme activity. This compound's unique methylation enhances its lipophilicity, promoting membrane permeability and facilitating rapid cellular uptake. Its distinct kinetic profile allows for modulation of nitric oxide production, while its acetate moiety may stabilize interactions with NOS3, optimizing enzyme-substrate complex formation and enhancing reaction rates. | ||||||
2-Imino-4-methylpiperidine acetate | 165383-72-2 | sc-202402 sc-202402A | 5 mg 25 mg | $30.00 $90.00 | ||
2-Imino-4-methylpiperidine acetate exhibits intriguing interactions with NOS3, primarily through its imino group, which can participate in hydrogen bonding and electrostatic interactions. This compound's structural flexibility allows it to adopt various conformations, potentially influencing its binding affinity. Additionally, the presence of the acetate group may enhance solubility in biological systems, facilitating effective diffusion and interaction kinetics, thereby modulating nitric oxide synthesis pathways. | ||||||
ARL 17477 dihydrochloride | 866914-87-6 | sc-361108 sc-361108A | 10 mg 50 mg | $129.00 $548.00 | ||
Selectively inhibits nNOS by disrupting calmodulin binding, leading to reduced NO production. | ||||||
Iromycin A | 213137-53-2 | sc-221763 sc-221763A | 500 µg 1 mg | $444.00 $638.00 | ||
Iromycin A demonstrates a unique affinity for NOS3, characterized by its ability to form stable complexes through specific non-covalent interactions. The compound's distinct cyclic structure allows for conformational adaptability, which may optimize its binding dynamics. Furthermore, its functional groups can engage in π-π stacking and hydrophobic interactions, potentially influencing the enzyme's catalytic activity and altering nitric oxide production pathways in a nuanced manner. | ||||||
S-Ethyl N-Phenylisothiourea | 19801-34-4 | sc-208326 | 50 mg | $330.00 | ||
S-Ethyl N-Phenylisothiourea exhibits a remarkable selectivity for NOS3, facilitated by its unique thiourea moiety that enhances hydrogen bonding with the enzyme's active site. This compound's electron-rich aromatic ring can participate in charge transfer interactions, modulating the enzyme's conformation. Additionally, its steric properties may influence substrate accessibility, thereby affecting reaction kinetics and the overall efficiency of nitric oxide synthesis. | ||||||