NOS3 Inhibitors
Santa Cruz Biotechnology now offers a broad range of NOS3 Inhibitors. Nitric oxide (NO) has a broad range of biological activities including cell signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS3 (also designated ecNOS), is a constitutive Ca2+/CaM-dependent form of NOS, which was first identified in endothelial cells. NOS3 Inhibitors offered by Santa Cruz inhibit NOS3 and, in some cases, other cell signaling and nitric oxide synthesis related proteins. View detailed NOS3 Inhibitor specifications, including NOS3 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 11 to 20 of 35 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
S-Ethylisothiourea HBr | 1071-37-0 | sc-200351 | 50 mg | $20.00 | 2 | |
S-Ethylisothiourea HBr acts as a selective modulator of NOS3 through its ability to form transient complexes with the enzyme's active site. This interaction alters the enzyme's dynamics, impacting substrate accessibility and reaction rates. The compound's hydrophilic characteristics enhance its interaction with polar environments, allowing for rapid cellular uptake. Furthermore, its unique thiourea moiety may influence hydrogen bonding patterns, contributing to its regulatory effects on nitric oxide synthesis. | ||||||
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) | 150403-88-6 | sc-200343 sc-200343A | 1 mg 100 mg | $194.00 $1428.00 | 4 | |
N(5)-(1-Iminoethyl)-L-ornithine HCl selectively inhibits NOS3 by competitively binding to the enzyme's active site, disrupting its catalytic function. This compound's unique structure allows for specific interactions with key amino acid residues, modulating enzyme conformation and activity. Its charged nature enhances solubility in aqueous environments, facilitating effective diffusion across cellular membranes. Additionally, the presence of the iminoethyl group may influence electron distribution, affecting reaction kinetics and nitric oxide production. | ||||||
NG-Amino-L-arginine hydrochloride | 1031799-40-2 | sc-222066 | 5 mg | $51.00 | ||
NG-Amino-L-arginine hydrochloride acts as a selective modulator of NOS3 by mimicking the substrate L-arginine, engaging in non-covalent interactions that stabilize the enzyme's inactive conformation. Its unique amino group configuration promotes hydrogen bonding with critical residues, altering the enzyme's dynamics. The compound's hydrophilic characteristics enhance its interaction with polar environments, potentially influencing the enzyme's localization and activity in various cellular contexts. | ||||||
L-NMMA (citrate) | sc-364686 sc-364686A sc-364686B | 10 mg 50 mg 100 mg | $58.00 $262.00 $468.00 | 1 | ||
L-NMMA (citrate) serves as a competitive inhibitor of NOS3, effectively disrupting the enzyme's catalytic cycle. Its structural similarity to L-arginine allows it to occupy the active site, preventing substrate binding. The presence of the citrate moiety enhances solubility and facilitates electrostatic interactions with the enzyme, potentially modulating its conformational states. This compound's unique ability to influence reaction kinetics may lead to altered nitric oxide production, impacting various signaling pathways. | ||||||
S-Methylisothiourea sulfate | 867-44-7 | sc-3566 sc-3566A | 1 g 100 g | $20.00 $23.00 | 8 | |
S-Methylisothiourea sulfate acts as a selective inhibitor of NOS3 by forming a stable complex with the enzyme, thereby hindering its activity. Its unique thiourea structure allows for specific hydrogen bonding and steric interactions with key amino acid residues in the active site. This compound can alter the enzyme's conformational dynamics, influencing the rate of nitric oxide synthesis and potentially affecting downstream signaling cascades. Its distinct reactivity profile highlights its role in modulating enzymatic function. | ||||||
4-Picoline | 108-89-4 | sc-238951 | 25 ml | $28.00 | ||
Disrupts nNOS dimerization and calmodulin binding, leading to decreased NO synthesis. | ||||||
N G-Nitro-L-arginine | 2149-70-4 | sc-3570 | 1 g | $19.00 | 4 | |
Competitively inhibits nNOS by binding to its active site, reducing nitric oxide (NO) production. | ||||||
3-Bromo-7-nitroindazole | 74209-34-0 | sc-200347 sc-200347A | 5 mg 25 mg | $20.00 $26.00 | 1 | |
Reversible nNOS inhibitor that reduces NO production through binding at the enzyme's active site. | ||||||
MEG (sulfate) | 3979-00-8 | sc-205381 sc-205381A | 5 mg 10 mg | $161.00 $255.00 | ||
MEG (sulfate) interacts with NOS3 through a unique mechanism that involves the formation of a transient intermediate, facilitating the modulation of nitric oxide production. Its sulfate group enhances solubility and promotes ionic interactions with the enzyme's active site, leading to altered reaction kinetics. This compound can influence the enzyme's structural flexibility, impacting substrate accessibility and the overall catalytic efficiency, thereby playing a critical role in cellular signaling pathways. | ||||||
AMT HYDROCHLORIDE | 21463-31-0 | sc-202052 sc-202052A | 10 mg 50 mg | $109.00 $419.00 | ||
AMT hydrochloride exhibits distinctive interactions with NOS3, characterized by its ability to form stable complexes that influence enzyme conformation. The presence of the hydrochloride moiety enhances its solubility, allowing for effective engagement with the active site. This compound can modulate electron transfer processes, affecting the kinetics of nitric oxide synthesis. Additionally, its unique steric properties may alter substrate binding dynamics, impacting overall enzymatic activity and signaling cascades. | ||||||