NOD2 Activators

Common NOD2 Activators include, but are not limited to Cholecalciferol CAS 67-97-0, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Butyric acid CAS 107-92-6, Curcumin CAS 458-37-7 and 3,3'-Diindolylmethane CAS 1968-05-4.

NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) is a protein involved in the immune response to intracellular bacterial components, particularly muramyl dipeptide (MDP) from bacterial peptidoglycan. Dysregulation of NOD2 is associated with certain diseases, such as Crohn's disease. NOD2 activators belong to a class of chemical compounds that interact with the Nucleotide-binding Oligomerization Domain-containing protein 2 (NOD2), a critical component of the innate immune system. NOD2 is a cytoplasmic pattern recognition receptor (PRR) that plays a pivotal role in detecting and responding to bacterial components, particularly the cell wall component known as muramyl dipeptide (MDP). When NOD2 recognizes MDP, it triggers a signaling cascade that leads to the activation of immune responses, including the production of inflammatory cytokines and antimicrobial peptides. These responses are essential for the host's defense against bacterial infections, as they help to eliminate the invading pathogens and restore tissue homeostasis.

NOD2 activators are compounds designed to modulate the activity of NOD2, either by enhancing or inhibiting its signaling pathways. This modulation can have significant implications for the immune response to bacterial infections and inflammation. Enhancing NOD2 activation can lead to a more robust immune response against bacterial invaders, which is particularly important in situations where the immune system needs reinforcement. Research into NOD2 activators is part of a broader effort to understand the intricate mechanisms of the immune system's response to infections and inflammation.