NMDA Activators
Santa Cruz Biotechnology now offers a broad range of NMDA Activators. Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. NMDA Activators offered by Santa Cruz activate NMDA and, in some cases, other neurotransmission and neural development related proteins. View detailed NMDA Activator specifications, including NMDA Activator CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 1 to 10 of 29 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Aspartic acid | 1783-96-6 | sc-202562 | 1 g | $30.00 | ||
D-Aspartic acid is an amino acid that plays a crucial role in neurotransmission, particularly as an agonist at NMDA receptors. Its unique structure allows for specific interactions with receptor sites, enhancing calcium ion influx and modulating synaptic plasticity. The compound's stereochemistry influences its binding affinity, while its ability to participate in metabolic pathways underscores its significance in cellular signaling. This dynamic behavior contributes to the intricate balance of excitatory neurotransmission. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $107.00 $362.00 | 2 | |
N-Methyl-D-Aspartic acid is a potent ligand that selectively targets NMDA receptors, characterized by its unique methyl group that enhances receptor affinity. This modification alters the compound's steric properties, facilitating distinct interactions with the receptor's binding site. Its kinetic profile reveals rapid association and dissociation rates, allowing for precise modulation of synaptic activity. Additionally, NMDA's role in calcium signaling pathways highlights its importance in cellular communication and excitatory neurotransmission dynamics. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine acts as a co-agonist of the NMDA receptor, binding to a site distinct from glutamate to trigger channel opening. | ||||||
1-Aminocyclopropane-1-carboxylic Acid | 22059-21-8 | sc-202393 | 500 mg | $140.00 | 2 | |
1-Aminocyclopropane-1-carboxylic Acid acts as a unique modulator of NMDA receptor activity, distinguished by its cyclopropane structure that introduces strain and flexibility in molecular interactions. This configuration allows for specific conformational changes upon binding, influencing receptor activation. Its reaction kinetics demonstrate a notable affinity for the receptor, promoting enhanced calcium influx and synaptic plasticity, thereby impacting neuronal signaling pathways. | ||||||
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) | 23052-81-5 | sc-200432 | 5 mg | $92.00 | 1 | |
L(+)-2-Amino-4-phosphonobutanoic acid is a selective antagonist of the NMDA receptor, characterized by its unique phosphonate group that mimics natural substrates. This structural feature facilitates specific binding interactions, altering receptor conformation and inhibiting calcium ion flow. Its kinetic profile reveals a rapid onset of action, effectively modulating excitatory neurotransmission and influencing synaptic dynamics, thereby playing a critical role in neuronal communication. | ||||||
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $42.00 $125.00 $200.00 | ||
Similar to glycine, D-serine binds to the co-agonist site on the NMDA receptor, facilitating its activation. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
L-Cysteine, a thiol-containing amino acid, exhibits unique interactions with NMDA receptors through its sulfhydryl group, which can form disulfide bonds and influence receptor activity. This reactivity allows it to modulate redox states within the synaptic environment, potentially affecting receptor sensitivity. Its participation in various metabolic pathways, including glutathione synthesis, highlights its role in cellular signaling and neuroprotection, impacting synaptic plasticity and neuronal health. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
As the primary agonist, L-glutamic acid directly binds to and activates the NMDA receptor. | ||||||
Putrescine dihydrochloride | 333-93-7 | sc-202786E sc-202786E-CW sc-202786 sc-202786A sc-202786B sc-202786C sc-202786D | 5 mg 5 mg 25 g 100 g 250 g 1 kg 5 kg | $23.00 $26.00 $31.00 $82.00 $143.00 $480.00 $2346.00 | 2 | |
Putrescine dihydrochloride, a biogenic amine, engages with NMDA receptors by influencing ion channel dynamics and modulating neurotransmitter release. Its unique structure allows for competitive inhibition at receptor sites, altering calcium influx and synaptic transmission. Additionally, it plays a role in cellular signaling pathways, potentially affecting neuronal excitability and plasticity. The compound's interaction with polyamines further underscores its significance in cellular growth and differentiation processes. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine can potentiate NMDA receptor currents by enhancing the receptor's sensitivity to glutamate. | ||||||