Nlk Activators
The chemical class known as NLK Activators encompasses a diverse group of compounds that can either directly activate NLK or indirectly influence NLK activation by targeting various pathways and cellular processes. NLK is involved in several signaling cascades, and these activators play crucial roles in regulating NLK function. Indirect NLK activators like Retinoic Acid, PGE2, 9-cis-Retinoic Acid, Forskolin, PMA, TPA, PGE1, 22(R)-Hydroxycholesterol, Calcitriol, 9,10-DHOME, Arachidonic Acid, and CDDO-Im influence NLK through various mechanisms. For example, Retinoic Acid activates the RA signaling pathway by binding to RARs, which regulate NLK-associated genes. PGE2 and PGE1 activate NLK through EP receptors, triggering intracellular signaling pathways. Forskolin raises intracellular cAMP levels, activating NLK via cAMP-dependent signaling.
PMA and TPA stimulate PKC, which phosphorylates and activates NLK. 22(R)-Hydroxycholesterol activates LXR, modulating NLK-related genes and pathways. Calcitriol activates NLK through the vitamin D signaling pathway by binding to VDR. 9,10-DHOME activates NLK by stimulating PPARγ, which regulates NLK-associated genes. Arachidonic Acid activates NLK via PPARδ, influencing NLK-related pathways. CDDO-Im activates NLK by inducing Nrf2, which regulates NLK-associated gene expression through the antioxidant response pathway. In summary, NLK activators encompass a diverse range of chemicals that can directly or indirectly modulate NLK function. These compounds are instrumental in elucidating the intricate roles of NLK in various signaling pathways and cellular processes, contributing to a better understanding of its regulatory mechanisms within cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is an indirect NLK activator. It can activate the RA signaling pathway by binding to its nuclear receptors, RARs (Retinoic Acid Receptors), which can regulate NLK-associated genes, leading to NLK activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 indirectly activates NLK by binding to its G protein-coupled receptors (EP receptors), which can trigger intracellular signaling pathways, including NLK activation through crosstalk with other signaling pathways. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-Retinoic Acid is an isomer of RA and indirectly activates NLK through the same mechanism by binding to RARs and influencing NLK-related gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates NLK by stimulating adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP can activate NLK through cAMP-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA indirectly activates NLK by activating PKC (Protein Kinase C), which can phosphorylate and activate NLK through downstream signaling events. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
PGE1 indirectly activates NLK through the same EP receptors as PGE2, initiating intracellular signaling pathways that can lead to NLK activation. | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $108.00 $350.00 $600.00 | 1 | |
22(R)-Hydroxycholesterol is an indirect NLK activator. It can activate LXR (Liver X Receptors), which can modulate NLK-associated genes and pathways, leading to NLK activation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol indirectly activates NLK by binding to the vitamin D receptor (VDR), which can influence NLK-associated gene expression and activation through the vitamin D signaling pathway. | ||||||
(±)9,10-DiHOME | 263399-34-4 | sc-205189 sc-205189A sc-205189B | 25 µg 50 µg 100 µg | $51.00 $98.00 $130.00 | ||
9,10-DHOME is an indirect NLK activator. It can activate PPARγ (Peroxisome Proliferator-Activated Receptor γ), which can regulate NLK-related genes and pathways, leading to NLK activation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic Acid is an indirect NLK activator. It can activate PPARδ (Peroxisome Proliferator-Activated Receptor δ), which can modulate NLK-associated genes and pathways, leading to NLK activation. | ||||||