NIPSNAP3B Inhibitors
NIPSNAP3B inhibitors are chemical compounds that specifically target and inhibit the activity of NIPSNAP3B, a protein that belongs to the NIPSNAP family of proteins. The NIPSNAP (Nipsnap Homolog 1) family is generally involved in various cellular processes, including signaling and metabolic pathways. NIPSNAP3B itself is associated with mitochondrial function, and its inhibition can lead to significant changes in cellular metabolism and energy homeostasis. Structurally, these inhibitors typically interact with key residues in the active or binding site of NIPSNAP3B, leading to a reduction or complete cessation of its activity. These interactions often involve hydrogen bonding, hydrophobic interactions, or coordination with metal ions if applicable, depending on the specific binding mechanism of the inhibitor. The design of NIPSNAP3B inhibitors may utilize high-throughput screening methods or computational approaches like molecular docking to identify small molecules that effectively bind to and block the protein's function.
From a biochemical perspective, the inhibition of NIPSNAP3B can influence mitochondrial dynamics, affecting processes such as oxidative phosphorylation, ATP production, and overall cellular energy balance. This makes NIPSNAP3B inhibitors useful tools for probing mitochondrial-related pathways in laboratory studies. The chemical diversity of these inhibitors ranges from small organic molecules to more complex peptides or natural product derivatives, depending on the method of discovery or design. The chemical properties of these inhibitors, such as their solubility, stability, and binding affinity, are critical factors in their efficiency and specificity in targeting NIPSNAP3B. Researchers may use NIPSNAP3B inhibitors to explore the protein's role in cellular metabolism and its broader implications in regulating energy-dependent biological processes, making them valuable in biochemical and molecular biology research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
This compound is a potent phosphoinositide 3-kinase (PI3K) inhibitor. NIPSNAP3B, being involved in vesicular transport processes, may be affected when PI3K signaling is inhibited, leading to a decrease in vesicle formation and trafficking, thus inhibiting NIPSNAP3B function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A chemical inhibitor of PI3K, which may impact vesicle trafficking by altering the phosphatidylinositol signaling pathway. Since NIPSNAP3B is implicated in vesicular transport, inhibition of PI3K can reduce the functional activity of NIPSNAP3B. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
This compound is an mTOR inhibitor. By inhibiting mTOR, which is involved in cellular growth and proliferation, the downstream effects can lead to reduced protein synthesis including that of vesicle-associated proteins, potentially impacting NIPSNAP3B's role in vesicular transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This small molecule disrupts the Golgi apparatus structure and inhibits protein transport from the endoplasmic reticulum to the Golgi. Considering NIPSNAP3B's involvement in vesicular transport, this disruption can lead to decreased functional activity of NIPSNAP3B in vesicle trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
An ionophore that disrupts Golgi function and alters intracellular protein transport. This can indirectly inhibit NIPSNAP3B by impeding vesicular trafficking pathways in which NIPSNAP3B is involved. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
By binding to tubulin, it inhibits microtubule polymerization, which is essential for vesicle trafficking. As NIPSNAP3B is associated with vesicular transport, microtubule disruption can impair NIPSNAP3B's functional activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
A microtubule stabilizer that can indirectly inhibit NIPSNAP3B by altering microtubule dynamics, which may affect vesicle transport processes that NIPSNAP3B is involved in. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An inhibitor of actin polymerization, affecting cytoskeleton organization and potentially influencing vesicular transport. Since NIPSNAP3B's role is linked to vesicle trafficking, disruption of the cytoskeleton may lead to reduced NIPSNAP3B activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A small molecule that inhibits dynamin, a GTPase involved in vesicle scission from membranes. As NIPSNAP3B is involved in vesicle trafficking, inhibiting dynamin could indirectly decrease NIPSNAP3B's functional activity in vesicle release. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule networks by binding to tubulin, thus affecting vesicle transport. Inhibition of microtubule dynamics can lead to an indirect decrease in the functional activity of NIPSNAP3B, which is involved in vesicular trafficking. | ||||||