NIMP Inhibitors
NIMP inhibitors refer to a class of compounds that specifically target and inhibit the function of the enzyme known as NAD+-dependent Isocitrate Dehydrogenase (NIMP). NIMP is involved in key metabolic pathways, such as the citric acid cycle, where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. This reaction is crucial for cellular respiration and energy production, as it contributes to the generation of reducing equivalents in the form of NADH, which are later used in oxidative phosphorylation to produce ATP. Inhibitors of NIMP work by binding to the active site of the enzyme, disrupting its ability to facilitate this critical metabolic reaction. This interference results in a modulation of cellular energy metabolism, which can have profound effects on the overall biochemical pathways within a cell, especially those dependent on the efficient production of NADH.
In terms of their chemical structure, NIMP inhibitors typically exhibit molecular features that allow them to bind tightly to the active site of the enzyme. These molecules often mimic the natural substrate, isocitrate, or the product, alpha-ketoglutarate, thus competitively inhibiting the enzyme's activity. However, some inhibitors may act through allosteric mechanisms, binding to a secondary site on the enzyme and inducing conformational changes that decrease its catalytic efficiency. The specificity and affinity of these inhibitors for NIMP are determined by various structural factors, including hydrogen bonding, hydrophobic interactions, and electrostatic complementarity with the enzyme's active or allosteric sites. The study of NIMP inhibitors provides insight into how precise control over enzymatic functions can lead to broad changes in metabolic flux, making them valuable tools for probing the complexity of metabolic networks and understanding cellular bioenergetics at a deeper level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a polyether antibiotic that disrupts sodium ion transport in cells. In cells expressing NIMP, disrupting sodium gradients can affect mitochondrial function, as NIMP is involved in mitochondrial homeostasis and membrane potential maintenance. By altering mitochondrial function, Monensin can inhibit NIMP's ability to support mitochondrial health and integrity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin is an inhibitor of the mitochondrial ATP synthase. Given that NIMP is associated with mitochondrial function, the inhibition of ATP synthase by Oligomycin leads to a collapse in the mitochondrial membrane potential. This collapse can inhibit the function of NIMP by disrupting the mitochondrial environment necessary for its proper function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A is an inhibitor of the mitochondrial electron transport chain, specifically complex III. By inhibiting complex III, Antimycin A causes a reduction in mitochondrial membrane potential, which is essential for the function of mitochondrial proteins like NIMP. This reduction can inhibit the proper functioning of NIMP by disrupting its mitochondrial context and potentially impairing its role in mitochondrial processes. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP is a protonophore that dissipates the proton gradient across the mitochondrial membrane, leading to a loss of mitochondrial membrane potential. NIMP, being a mitochondrial protein, relies on a proper membrane potential for its function. The dissipation caused by CCCP can, therefore, inhibit NIMP's function by impairing the mitochondrial membrane potential it requires. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting complex I and thereby decreasing mitochondrial respiration, Rotenone reduces the mitochondrial membrane potential. A reduced membrane potential can inhibit NIMP function as it may rely on an electrochemical gradient to maintain its structural integrity and function within the mitochondria. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione is known to disrupt mitochondrial electron transport and induce reactive oxygen species (ROS) production. An increase in ROS can damage mitochondrial components, affecting proteins like NIMP that are involved in maintaining mitochondrial integrity. This oxidative stress can inhibit the function of NIMP by impairing its structural or functional integrity within the mitochondria. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline can inhibit mitochondrial protein synthesis by binding to the 30S ribosomal subunit, which is similar to bacterial ribosomes. Since NIMP is a mitochondrial protein, its proper synthesis and function can be inhibited by tetracycline as it may prevent the translation of mitochondrial-encoded proteins, leading to a dysfunctional mitochondrial network. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine is an herbicide that has been shown to disrupt mitochondrial function by inhibiting photosynthetic and respiratory electron transport chains in plants. In animal cells, Atrazine might also impair mitochondrial function, potentially inhibiting NIMP by disrupting its mitochondrial environment, leading to a loss of mitochondrial membrane potential and affecting its functionality. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat is a redox cycling agent that can increase the production of superoxide anions in mitochondria, leading to oxidative stress. For NIMP, which is involved in maintaining mitochondrial health, the oxidative damage caused by Paraquat can inhibit its function by inducing mitochondrial dysfunction and impairing the electrochemical gradient needed for its activity. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $400.00 | 10 | |
Bongkrekic Acid is an inhibitor of the adenine nucleotide translocase (ANT) in mitochondria, which is essential for maintaining the ADP/ATP exchange across the mitochondrial inner membrane. Inhibition of ANT can lead to mitochondrial dysfunction, which in turn can inhibit NIMP function as it relies on a proper mitochondrial environment for its activity. | ||||||