NFYB Activators
NFYB, or Nuclear Transcription Factor Y Subunit Beta, is a pivotal component of the trimeric NF-Y complex, which plays an essential role in the transcriptional regulation of numerous genes. The NF-Y complex, composed of three subunits (NFYA, NFYB, and NFYC), is distinguished by its ability to specifically bind to the CCAAT box, a crucial promoter element that is ubiquitous in eukaryotic genes. The presence of this complex is critical for the initiation of transcription in various genes implicated in a wide array of biological processes, including cell cycle progression, differentiation, and response to stress. The role of NFYB within this complex is particularly important as it contributes to the DNA-binding and transcriptional activity of the entire NF-Y complex. This transcriptional regulation is a highly orchestrated process, involving the precise interaction of NFYB with other subunits and the recruitment of additional coactivators or corepressors that modulate gene expression.
The expression of NFYB itself is subject to regulation by various chemical compounds, which can serve as activators, leading to its upregulation. These activators engage with cellular mechanisms at multiple levels, from transcription factor activation to epigenetic modifications. For instance, compounds like retinoic acid and vitamin D3 can stimulate the transcription of NFYB by interacting with their respective receptors, which then bind to specific sites on DNA to promote gene expression. Histone deacetylase inhibitors, such as Trichostatin A and sodium butyrate, induce a relaxed chromatin structure, thereby enhancing the accessibility of transcription factors to the NFYB gene promoter. Moreover, agents like Forskolin and lithium chloride can initiate signaling cascades that culminate in the phosphorylation and activation of proteins involved in the transcriptional machinery, thereby amplifying the expression of NFYB. Through such diverse mechanisms, these chemical activators can orchestrate the upregulation of NFYB expression, reflecting the intricate network of cellular signaling pathways that govern gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can upregulate gene expression by binding to retinoic acid receptors, which may directly interact with NF-Y binding sites, potentially stimulating NFYB transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, leading to the activation of protein kinase A (PKA), which can phosphorylate transcription factors and co-activators involved in the expression of NFYB. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
The active metabolite of Cholecalciferol can bind to the vitamin D receptor (VDR), which may form a complex with transcription factors such as NF-Y, stimulating the transcription of NFYB. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can cause hyperacetylation of histones, leading to a more open chromatin structure that may facilitate the recruitment of NF-Y to its target promoters, including that of NFYB. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can inhibit DNA methylation, potentially leading to the demethylation of the NFYB promoter, which may remove silencing marks and result in increased transcription of the NFYB gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, by inhibiting histone deacetylases, causes increased histone acetylation, which can lead to an enhancement of the transcriptional machinery's access to the NFYB gene, resulting in its increased expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may activate SIRT1, leading to the deacetylation of transcription factors or coactivators involved with NF-Y, which can lead to an upsurge in NFYB gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may trigger a cascade of events leading to the alteration of chromatin dynamics, which can stimulate the transcriptional activity of genes, including the gene coding for NFYB. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which can result in the stabilization and activation of transcription factors that enhance the expression of NFYB. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, through the glucocorticoid receptor, can lead to the recruitment of coactivators and the assembly of transcriptional machinery at the NFYB promoter, leading to increased expression. | ||||||