NELF-B Activators

NELF-B activators denote a series of compounds that have the potential to indirectly influence the NELF-B protein through the modulation of RNA polymerase II activity or the phosphorylation status of RNA polymerase II. This class of chemicals can be further categorized based on their specific targets and mechanisms of action. For instance, activators enact their influence by binding directly to RNA polymerase II and inhibiting its function. As the NELF-B protein forms a critical component of the NELF complex, which plays a significant role in pausing RNA polymerase II during transcription, the inhibition of RNA polymerase II can translate to an indirect influence on the NELF-B protein.

On the other hand, NELF-B activators class operate by inhibiting cyclin-dependent kinases (CDKs). These activators are characterized by their ability to alter the phosphorylation status of RNA polymerase II, thereby indirectly influencing NELF-B. Additionally, activators target and inhibit the protein BRD4. BRD4 is responsible for recruiting P-TEFb, a kinase essential for phosphorylating RNA polymerase II. The inhibition of BRD4 thus affects the recruitment of P-TEFb, indirectly influencing the function of NELF-B.