NECAP 2 Inhibitors

NECAP 2 Inhibitors primarily encompasses compounds that have an indirect impact on the function of NECAP 2. NECAP 2 is implicated in clathrin-mediated endocytosis, a fundamental process by which cells internalize external substances. Dynasore, Dyngo-4a, and MiTMAB are all inhibitors of dynamin, a GTPase required for the scission of newly formed vesicles during endocytosis. The disruption of dynamin can result in the accumulation of clathrin-coated pits at the plasma membrane. Pitstop 2, Chlorpromazine (CPZ), and MDC target clathrin itself or its associated adaptor proteins, thus inhibiting the formation of clathrin-coated vesicles. This blockage results in a diminished ability for the cell to undergo regulated endocytosis.

Genistein, Phenylarsine oxide, and the PI3K inhibitors (Wortmannin and LY294002) operate by modulating enzymatic pathways that play supportive roles in clathrin-mediated endocytosis. Their inhibition can indirectly curb the function of proteins like NECAP 2. EIPA is unique in this list as it inhibits macropinocytosis, a distinct endocytic pathway, signifying that cells might upregulate alternative endocytic pathways when clathrin-mediated processes are inhibited.