NDUFB11 Activators
NDUFB11 is a crucial protein in the human body, encoded by the NDUFB11 gene. It constitutes a vital subunit within Complex I of the mitochondrial respiratory chain, a system that serves to transfer electrons from NADH to the respiratory chain. The protein is predominantly localized within the mitochondria, the cell's powerhouse, where it plays a significant role in energy production. These functions underscore the importance of NDUFB11 in the mitochondrial respiratory chain and its overall contribution to cellular energy homeostasis. Variations or mutations in the NDUFB11 gene have been known to be associated with Complex I deficiency, emphasizing the protein's essential role in maintaining effective cellular energy production.
A variety of chemical compounds, both natural and synthetic, have been found to induce the expression of proteins like NDUFB11. These chemicals generally function by enhancing mitochondrial function and biogenesis or activating certain cellular pathways that lead to increased production of mitochondrial proteins. For example, Resveratrol, a polyphenolic compound, and Quercetin, a flavonoid, stimulate mitochondrial biogenesis by activating the SIRT1/PGC-1α pathway. Similarly, Metformin and Berberine act indirectly through the AMPK pathway, a central regulator of cellular energy homeostasis. On the other hand, compounds like Curcumin, EGCG, and Sulforaphane operate by triggering the Nrf2 pathway, a key regulator of mitochondrial biogenesis and function. Other compounds like Alpha-lipoic acid and Coenzyme Q10 enhance mitochondrial biogenesis through various mechanisms. Finally, Nicotinamide riboside, a form of vitamin B3, and Pterostilbene, a stilbenoid chemically related to Resveratrol, boost the expression of proteins like NDUFB11 through their actions on cellular energy production.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, has been shown to induce the upregulation of mitochondrial proteins. It achieves this by triggering the activation of SIRT1, a protein known for governing mitochondrial function and biogenesis, thereby potentially fostering an increase in NDUFB11 expression. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin, a biguanide derivative, has the capacity to indirectly stimulate the activity of AMPK, a central player in maintaining cellular energy homeostasis. This AMPK activation might incite an increase in mitochondrial biogenesis, subsequently encouraging the production of mitochondrial proteins like NDUFB11. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine, an isoquinoline alkaloid, has been demonstrated to reinforce mitochondrial function and biogenesis. It potentially achieves this through the activation of the AMPK pathway, which may incite an upsurge in NDUFB11 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, is known to stimulate mitochondrial biogenesis. It accomplishes this through the activation of the SIRT1/PGC-1α pathway, which might catalyze an increase in NDUFB11 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a curcuminoid of turmeric, has the ability to trigger the Nrf2 pathway. This pathway is a key facilitator of mitochondrial biogenesis and function, thereby potentially fostering an increase in the expression of mitochondrial proteins like NDUFB11. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid, an organosulfur compound, has been shown to bolster mitochondrial biogenesis through the activation of the AMPK/PGC-1α pathway, which might instigate an upsurge in NDUFB11 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a polyphenol found in green tea, holds the ability to stimulate the Nrf2 pathway. This pathway plays a key role in the regulation of mitochondrial biogenesis and function, thereby potentially inducing the expression of mitochondrial proteins like NDUFB11. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, a sulfur-rich compound found in cruciferous vegetables, can stimulate the Nrf2 pathway, a critical element in the regulation of mitochondrial biogenesis and function. This action might thereby foster the increase in expression of mitochondrial proteins like NDUFB11. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10, an essential component of the electron transport chain, has been found to invigorate mitochondrial biogenesis. This effect could lead to an amplified expression of mitochondrial proteins such as NDUFB11. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside, a variant of vitamin B3, serves as a precursor for NAD+, an essential coenzyme for mitochondrial function. This action may stimulate the production of proteins like NDUFB11. | ||||||