NDUFAF7 Activators

Chemical activators of N6-furfuryladenine can play a significant role in enhancing the functional activity of NDUFAF7, a protein integral to the assembly of mitochondrial Complex I. N6-furfuryladenine is known to activate adenine nucleotide translocator (ANT), which interacts with NDUFAF7 during the assembly process of Complex I, leading to an increase in ATP synthesis. This activation is further supported by the presence of Spermidine, which enhances autophagy, subsequently improving the turnover and assembly of mitochondrial complexes. The improved assembly of these complexes augments the activity of NDUFAF7. Coenzyme Q10, by participating in the electron transport chain, enhances electron flow, facilitating the assembly and activity of Complex I and indirectly supporting NDUFAF7's role. Cardiolipin, essential to the inner mitochondrial membrane, aids in the optimal functioning of Complex I, promoting the proper assembly and function of mitochondrial complexes, thus enhancing NDUFAF7's activity.

Additionally, Nicotinamide adenine dinucleotide (NADH) as a Complex I substrate, enhances the complex's activity, leading to increased activity of NDUFAF7. L-carnitine assists in the transport of fatty acids into mitochondria for β-oxidation, increasing the production of NADH and FADH2, which in turn enhances Complex I activity and NDUFAF7's functional activity. Mitoquinone mesylate, a targeted antioxidant, maintains the integrity of mitochondrial complexes and supports NDUFAF7's role in Complex I assembly. Copper (II) sulfate ensures the proper function of the electron transport chain, indirectly promoting NDUFAF7 activity. Alpha-lipoic acid serves as a mitochondrial cofactor and antioxidant, improving function and indirectly enhancing NDUFAF7 activity. Furthermore, Retinoic acid influences mitochondrial biogenesis and function, increasing NDUFAF7 activity. Leucine stimulates the mTOR pathway, leading to mitochondrial biogenesis and function, enhancing NDUFAF7 activity. Pyrroloquinoline quinone (PQQ) influences mitochondrial biogenesis and function, further supporting the activity of NDUFAF7.