Myosin VI Inhibitors
Myosin VI inhibitors are chemical compounds designed to specifically target and inhibit the function of Myosin VI, a unique motor protein involved in various intracellular transport and anchoring processes. Myosin VI is an actin-based motor that moves toward the minus end of actin filaments, a direction opposite to most myosins, making it essential for functions such as endocytosis, membrane trafficking, and maintaining the structure of cellular compartments. It plays a pivotal role in transporting cargo such as vesicles, organelles, and protein complexes within cells. By inhibiting Myosin VI, these compounds block its ATPase activity or interfere with its ability to bind and walk along actin filaments, thereby halting its intracellular transport functions.
Chemically, Myosin VI inhibitors are typically small molecules that bind to specific regions of the protein, such as the motor domain responsible for ATP hydrolysis or the actin-binding sites that are essential for its movement along filaments. These inhibitors might function by either preventing Myosin VI from hydrolyzing ATP, thus halting its energy-driven motility, or by disrupting its attachment to actin, which is critical for its transport role. Inhibiting Myosin VI allows researchers to dissect the specific contributions of this motor protein to various cellular processes, particularly in endocytic pathways and organelle positioning. These inhibitors are valuable in studying the molecular mechanisms by which Myosin VI regulates cellular dynamics, and they provide insight into the broader roles of actin-based motors in maintaining cellular organization and facilitating intracellular communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may downregulate Myosin VI by preventing deacetylation of histones near its promoter region, thus maintaining a condensed chromatin structure that is less accessible for transcription machinery. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could decrease Myosin VI expression by inhibiting DNA methylation, potentially leading to the repression of gene transcription through alterations in the epigenetic landscape. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could suppress Myosin VI expression by inhibiting the mTORC1 signaling pathway, which is crucial for cap-dependent translation initiation of many proteins. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D may inhibit the transcription of Myosin VI by binding to the DNA template, obstructing the elongation phase of RNA synthesis by RNA polymerase. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide may reduce Myosin VI levels by blocking the translocation step in mRNA translation, thereby halting the elongation of the nascent protein chain. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin could decrease Myosin VI synthesis by causing premature release of the nascent polypeptide chain from the ribosome during translation, leading to incomplete protein products. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine may decrease Myosin VI levels by disrupting endosomal acidification and lysosomal function, which could lead to altered processing of transcriptional regulators. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin may downregulate Myosin VI by stabilizing the DNA-topoisomerase I complex, inducing DNA breaks that trigger a cellular response halting transcription initiation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may attenuate Myosin VI expression by inhibiting kinase pathways that activate transcription factors necessary for the expression of the Myosin VI gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could reduce Myosin VI expression by activating sirtuins that deacetylate histones associated with the Myosin VI gene, leading to tighter chromatin structure and reduced access for transcription factors. | ||||||